Viability and apoptosis in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20217)

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Small Molecule Cell Line Drug Concentration Conc Unit Time Point Time Point Unit Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction Replicate
AZ-628 COLO 858 0.3160
uM
 48
hr
 2126 503 0.3708 0.3684 0.2366 0.2211 1
AZ-628 COLO 858 0.3160
uM
 48
hr
 2005 429 0.3601 0.3684 0.2140 0.2211 2
SB590885 SKMEL28 3.1600
uM
 72
hr
 687 162 0.3938 0.3728 0.2358 0.2588 4
SB590885 SKMEL28 3.1600
uM
 72
hr
 673 176 0.3728 0.3728 0.2615 0.2588 1
SB590885 SKMEL28 3.1600
uM
 72
hr
 714 158 0.4171 0.3728 0.2213 0.2588 3
SB590885 SKMEL28 3.1600
uM
 72
hr
 600 190 0.3076 0.3728 0.3167 0.2588 2
Selumetinib COLO 858 1.0000
uM
 48
hr
 2054 398 0.3784 0.3740 0.1938 0.2319 1
Selumetinib COLO 858 1.0000
uM
 48
hr
 1935 372 0.3571 0.3740 0.1923 0.2319 2
Selumetinib COLO 858 1.0000
uM
 48
hr
 2321 616 0.3896 0.3740 0.2654 0.2319 4
Selumetinib COLO 858 1.0000
uM
 48
hr
 2243 619 0.3711 0.3740 0.2760 0.2319 3
SB590885 COLO 858 1.0000
uM
 72
hr
 1260 372 0.3226 0.3809 0.2952 0.2676 1
SB590885 COLO 858 1.0000
uM
 72
hr
 1559 383 0.4272 0.3809 0.2457 0.2676 3
SB590885 COLO 858 1.0000
uM
 72
hr
 1540 408 0.4112 0.3809 0.2649 0.2676 4
SB590885 COLO 858 1.0000
uM
 72
hr
 1357 359 0.3625 0.3809 0.2646 0.2676 2
PLX-4720 MZ7-mel 1.0000
uM
 72
hr
 972 85 0.3695 0.3821 0.0874 0.1052 4
PLX-4720 MZ7-mel 1.0000
uM
 72
hr
 916 82 0.3474 0.3821 0.0895 0.1052 1
PLX-4720 MZ7-mel 1.0000
uM
 72
hr
 841 130 0.2962 0.3821 0.1546 0.1052 2
PLX-4720 MZ7-mel 1.0000
uM
 72
hr
 1358 121 0.5153 0.3821 0.0891 0.1052 3
SB590885 MZ7-mel 3.1600
uM
 72
hr
 1019 155 0.3599 0.3870 0.1521 0.1433 1
SB590885 MZ7-mel 3.1600
uM
 72
hr
 939 140 0.3328 0.3870 0.1491 0.1433 2
SB590885 MZ7-mel 3.1600
uM
 72
hr
 1179 161 0.4241 0.3870 0.1366 0.1433 3
SB590885 MZ7-mel 3.1600
uM
 72
hr
 1197 162 0.4311 0.3870 0.1353 0.1433 4
PLX-4720 SKMEL28 3.1600
uM
 72
hr
 617 60 0.4178 0.3891 0.0972 0.1047 4
PLX-4720 SKMEL28 3.1600
uM
 72
hr
 625 65 0.4201 0.3891 0.1040 0.1047 3
PLX-4720 SKMEL28 3.1600
uM
 72
hr
 547 61 0.3646 0.3891 0.1115 0.1047 2