Viability and apoptosis in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20217)
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| Small Molecule | Cell Line | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Total Number of Cells (Nuclei) | Number of Apoptotic Cells | Relative Viability | Mean Relative Viability | Apoptosis Fraction | Mean Apoptosis Fraction | Replicate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Selumetinib | MZ7-mel | 0.0316 | uM | 24 | hr | 1686 | 32 | 1.2530 | 1.1074 | 0.0190 | 0.0129 | 1 |
| AZ-628 | MZ7-mel | 0.0100 | uM | 72 | hr | 2577 | 49 | 1.0530 | 1.1122 | 0.0190 | 0.0145 | 3 |
| SB590885 | MZ7-mel | 0.3160 | uM | 48 | hr | 2216 | 42 | 0.6731 | 0.6703 | 0.0190 | 0.0253 | 4 |
| MZ7-mel | 0.0000 | uM | 72 | hr | 2037 | 39 | 0.8323 | 0.0191 | 3 | |||
| Vemurafenib | MZ7-mel | 0.0100 | uM | 24 | hr | 1775 | 34 | 1.3189 | 1.1080 | 0.0192 | 0.0131 | 1 |
| SB590885 | MZ7-mel | 0.1000 | uM | 72 | hr | 1704 | 33 | 0.6961 | 0.6143 | 0.0194 | 0.0271 | 2 |
| AZ-628 | MZ7-mel | 0.0032 | uM | 48 | hr | 3199 | 62 | 0.9712 | 1.0337 | 0.0194 | 0.0137 | 2 |
| AZ-628 | MZ7-mel | 0.0032 | uM | 24 | hr | 1342 | 26 | 0.9970 | 1.0250 | 0.0194 | 0.0132 | 4 |
| SB590885 | MZ7-mel | 0.0100 | uM | 48 | hr | 3287 | 64 | 0.9978 | 0.9679 | 0.0195 | 0.0190 | 3 |
| PLX-4720 | MZ7-mel | 0.1000 | uM | 72 | hr | 1535 | 30 | 0.6269 | 0.6612 | 0.0195 | 0.0198 | 2 |
| AZ-628 | MZ7-mel | 0.0100 | uM | 48 | hr | 2925 | 57 | 0.8879 | 1.0431 | 0.0195 | 0.0171 | 2 |
| SB590885 | MZ7-mel | 0.0316 | uM | 48 | hr | 3320 | 65 | 1.0077 | 0.9913 | 0.0196 | 0.0145 | 2 |
| PLX-4720 | WM1552C | 0.3160 | uM | 48 | hr | 2026 | 40 | 0.6318 | 0.8386 | 0.0197 | 0.0440 | 4 |
| MZ7-mel | 0.0000 | uM | 72 | hr | 2376 | 47 | 0.9702 | 0.0198 | 4 | |||
| Vemurafenib | MZ7-mel | 0.0316 | uM | 48 | hr | 3471 | 69 | 1.0532 | 1.0675 | 0.0199 | 0.0196 | 4 |
| MZ7-mel | 0.0000 | uM | 48 | hr | 3444 | 69 | 1.0449 | 0.0200 | 3 | |||
| SB590885 | K2 | 1.0000 | uM | 24 | hr | 1194 | 24 | 0.6881 | 1.0860 | 0.0201 | 0.0129 | 4 |
| MZ7-mel | 0.0000 | uM | 48 | hr | 3854 | 78 | 1.1690 | 0.0202 | 3 | |||
| Selumetinib | MZ7-mel | 0.1000 | uM | 48 | hr | 2607 | 53 | 0.7907 | 0.7966 | 0.0203 | 0.0195 | 1 |
| PLX-4720 | MZ7-mel | 0.0316 | uM | 48 | hr | 3355 | 68 | 1.0176 | 1.0185 | 0.0203 | 0.0130 | 4 |
| SB590885 | MZ7-mel | 0.0032 | uM | 72 | hr | 2793 | 57 | 1.1397 | 1.2285 | 0.0204 | 0.0170 | 3 |
| Selumetinib | LOXIMVI | 0.0316 | uM | 24 | hr | 2396 | 49 | 0.9584 | 1.0215 | 0.0205 | 0.0293 | 3 |
| Selumetinib | MZ7-mel | 0.3160 | uM | 24 | hr | 1658 | 34 | 1.2303 | 1.0672 | 0.0205 | 0.0210 | 2 |
| AZ-628 | SKMEL28 | 0.0316 | uM | 72 | hr | 1171 | 24 | 0.8604 | 0.7910 | 0.0205 | 0.0262 | 3 |
| MZ7-mel | 0.0000 | uM | 48 | hr | 3618 | 74 | 1.0972 | 0.0205 | 3 |