Viability and apoptosis in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20217)

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Small Molecule Cell Line Drug Concentration Conc Unit Time Point Time Point Unit Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction Replicate
Selumetinib K2 0.1000
uM
 24
hr
 1611 13 0.9398 0.6297 0.0081 0.0128 2
MZ7-mel 0.0000
uM
 48
hr
 3589 29 1.1022 0.0081 1
MZ7-mel 0.0000
uM
 72
hr
 2719 22 1.1234 0.0081 2
Vemurafenib MZ7-mel 0.1000
uM
 48
hr
 3328 27 1.0220 1.0699 0.0081 0.0148 2
SB590885 K2 0.3160
uM
 48
hr
 4171 34 1.5098 1.3267 0.0082 0.0089 2
PLX-4720 K2 0.3160
uM
 24
hr
 1345 11 0.7846 0.9548 0.0082 0.0082 3
MZ7-mel 0.0000
uM
 24
hr
 1341 11 1.0076 0.0082 3
K2 0.0000
uM
 24
hr
 1714 14 0.9998 0.0082 2
PLX-4720 K2 0.1000
uM
 48
hr
 1925 16 0.6967 0.8459 0.0083 0.0053 4
PLX-4720 MZ7-mel 0.1000
uM
 24
hr
 1449 12 1.0886 1.1936 0.0083 0.0050 4
MZ7-mel 0.0000
uM
 24
hr
 1327 11 0.9970 0.0083 4
AZ-628 K2 0.1000
uM
 24
hr
 1324 11 0.7722 1.3258 0.0083 0.0060 3
PLX-4720 K2 0.0032
uM
 24
hr
 2959 25 1.7256 1.6766 0.0084 0.0050 3
Selumetinib MZ7-mel 0.0032
uM
 24
hr
 1434 12 1.0773 1.0295 0.0084 0.0105 2
MZ7-mel 0.0000
uM
 48
hr
 3192 27 0.9799 0.0085 2
Selumetinib MZ7-mel 0.0100
uM
 48
hr
 3164 27 0.9712 1.0123 0.0085 0.0157 2
MZ7-mel 0.0000
uM
 48
hr
 3479 30 1.0678 0.0086 1
Vemurafenib MZ7-mel 0.3160
uM
 24
hr
 1867 16 1.4023 1.1498 0.0086 0.0118 2
AZ-628 MZ7-mel 0.1000
uM
 24
hr
 1742 15 1.3083 1.1884 0.0086 0.0081 2
PLX-4720 MZ7-mel 0.3160
uM
 24
hr
 1389 12 1.0432 1.1278 0.0086 0.0092 4
Selumetinib K2 0.3160
uM
 24
hr
 1150 10 0.6705 0.4918 0.0087 0.0266 2
Selumetinib K2 0.0316
uM
 24
hr
 1248 11 0.7275 1.0203 0.0088 0.0045 3
MZ7-mel 0.0000
uM
 24
hr
 1256 11 0.9432 0.0088 3
Selumetinib MZ7-mel 0.0100
uM
 24
hr
 1345 12 1.0098 1.1333 0.0089 0.0133 3
AZ-628 MZ7-mel 0.1000
uM
 24
hr
 1334 12 1.0015 1.1884 0.0090 0.0081 3