Viability and apoptosis in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20217)

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Small Molecule Cell Line Drug Concentration Conc Unit Time Point Time Point Unit Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction Replicate
AZ-628 K2 0.1000
uM
 24
hr
 1919 13 1.1210 1.3258 0.0068 0.0060 4
Selumetinib MZ7-mel 0.0316
uM
 48
hr
 3464 24 1.0650 1.0395 0.0069 0.0142 1
PLX-4720 MZ7-mel 0.0316
uM
 48
hr
 3057 21 0.9399 1.0185 0.0069 0.0130 2
MZ7-mel 0.0000
uM
 48
hr
 3411 24 1.0486 0.0070 1
Selumetinib K2 0.0316
uM
 48
hr
 2273 16 0.8237 0.8224 0.0070 0.0058 3
Vemurafenib K2 0.3160
uM
 24
hr
 1706 12 0.9963 1.5894 0.0070 0.0047 4
AZ-628 MZ7-mel 0.0032
uM
 24
hr
 1288 9 0.9689 1.0250 0.0070 0.0132 3
Selumetinib MZ7-mel 0.0100
uM
 48
hr
 2921 21 0.8978 1.0123 0.0072 0.0157 1
MZ7-mel 0.0000
uM
 24
hr
 1656 12 1.2455 0.0072 1
K2 0.0000
uM
 48
hr
 2757 20 0.9989 0.0073 2
AZ-628 K2 0.0316
uM
 48
hr
 2725 20 0.9872 1.1133 0.0073 0.0048 3
Vemurafenib K2 0.3160
uM
 48
hr
 3529 26 1.2784 1.1238 0.0074 0.0116 2
MZ7-mel 0.0000
uM
 48
hr
 2789 21 0.8570 0.0075 2
K2 0.0000
uM
 24
hr
 2368 18 1.3821 0.0076 4
MZ7-mel 0.0000
uM
 48
hr
 3037 23 0.9331 0.0076 1
K2 0.0000
uM
 24
hr
 1033 8 0.6028 0.0077 3
K2 0.0000
uM
 24
hr
 1296 10 0.7563 0.0077 3
MZ7-mel 0.0000
uM
 24
hr
 1563 12 1.1750 0.0077 1
SB590885 MZ7-mel 0.1000
uM
 24
hr
 1564 12 1.1758 1.0949 0.0077 0.0118 1
Selumetinib MZ7-mel 0.0100
uM
 24
hr
 1430 11 1.0750 1.1333 0.0077 0.0133 4
SB590885 K2 0.0032
uM
 24
hr
 2566 20 1.4974 1.5537 0.0078 0.0059 3
SB590885 MZ7-mel 0.0316
uM
 48
hr
 3352 26 1.0297 0.9913 0.0078 0.0145 1
MZ7-mel 0.0000
uM
 24
hr
 1539 12 1.1568 0.0078 1
Selumetinib MZ7-mel 0.0032
uM
 24
hr
 1511 12 1.1356 1.0295 0.0079 0.0105 1
MZ7-mel 0.0000
uM
 24
hr
 1249 10 0.9386 0.0080 3