Viability and apoptosis in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20217)

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Small Molecule Cell Line Drug Concentration Conc Unit Time Point Time Point Unit Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction Replicate
AZ-628 C32 3.1600
uM
 72
hr
 1133 1071 0.0271 0.0269 0.9453 0.9414 4
Vemurafenib C32 1.0000
uM
 72
hr
 1032 733 0.1305 0.1615 0.7103 0.6577 2
Vemurafenib C32 1.0000
uM
 72
hr
 1017 691 0.1423 0.1615 0.6795 0.6577 1
Selumetinib COLO 858 0.1000
uM
 72
hr
 1382 128 0.4555 0.5449 0.0926 0.0769 3
Selumetinib C32 0.0100
uM
 72
hr
 2817 218 1.1347 0.9982 0.0774 0.0822 4
Selumetinib C32 0.0316
uM
 72
hr
 2486 98 1.0426 0.9520 0.0394 0.0406 4
PLX-4720 C32 0.1000
uM
 72
hr
 2073 69 0.8750 0.9374 0.0333 0.0354 1
Vemurafenib C32 3.1600
uM
 72
hr
 998 921 0.0336 0.0274 0.9229 0.9276 1
PLX-4720 C32 0.1000
uM
 72
hr
 2304 100 0.9623 0.9374 0.0434 0.0354 2
Selumetinib C32 0.0032
uM
 72
hr
 1708 247 0.6379 0.8911 0.1446 0.1032 1
Selumetinib C32 0.0032
uM
 72
hr
 2216 206 0.8776 0.8911 0.0930 0.1032 2
Selumetinib C32 0.0032
uM
 72
hr
 2515 203 1.0094 0.8911 0.0807 0.1032 3
Selumetinib C32 0.0032
uM
 72
hr
 2629 248 1.0396 0.8911 0.0943 0.1032 4
PLX-4720 C32 0.1000
uM
 72
hr
 2227 68 0.9426 0.9374 0.0305 0.0354 4
SB590885 C32 0.0316
uM
 72
hr
 2637 79 1.1168 1.0834 0.0300 0.0299 1
SB590885 C32 1.0000
uM
 72
hr
 1164 580 0.2550 0.2758 0.4983 0.4735 1
Selumetinib C32 0.0316
uM
 72
hr
 2047 83 0.8575 0.9520 0.0405 0.0406 2
C32 0.0000
uM
 72
hr
 2590 219 1.0352 0.0846 1
Selumetinib C32 0.0316
uM
 72
hr
 2088 86 0.8741 0.9520 0.0412 0.0406 1
C32 0.0000
uM
 72
hr
 2711 175 1.1072 0.0646 1
SB590885 C32 0.0316
uM
 72
hr
 2397 63 1.0190 1.0834 0.0263 0.0299 2
Selumetinib C32 0.0100
uM
 72
hr
 2202 144 0.8985 0.9982 0.0654 0.0822 1
Selumetinib C32 0.0100
uM
 72
hr
 2393 196 0.9592 0.9982 0.0819 0.0822 2
Selumetinib COLO 858 1.0000
uM
 72
hr
 1188 367 0.2982 0.3419 0.3089 0.2586 3
Selumetinib COLO 858 1.0000
uM
 72
hr
 1227 275 0.3458 0.3419 0.2241 0.2586 2