Viability and apoptosis in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20217)

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Small Molecule Cell Line Drug Concentration Conc Unit Time Point Time Point Unit Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction Replicate
Vemurafenib C32 3.1600
uM
 48
hr
 1537 1306 0.1124 0.1016 0.8497 0.8624 3
AZ-628 C32 1.0000
uM
 48
hr
 1504 1277 0.1105 0.1086 0.8491 0.8467 1
Selumetinib C32 3.1600
uM
 72
hr
 1035 878 0.0685 0.0615 0.8483 0.8621 2
Selumetinib C32 3.1600
uM
 48
hr
 1550 1314 0.1148 0.1270 0.8477 0.8303 2
AZ-628 C32 1.0000
uM
 48
hr
 1387 1163 0.1090 0.1086 0.8385 0.8467 2
AZ-628 WM-115 3.1600
uM
 72
hr
 1146 960 0.0614 0.0874 0.8377 0.8202 1
AZ-628 C32 1.0000
uM
 48
hr
 1469 1230 0.1163 0.1086 0.8373 0.8467 4
Selumetinib C32 3.1600
uM
 48
hr
 1464 1224 0.1168 0.1270 0.8361 0.8303 1
Selumetinib C32 3.1600
uM
 72
hr
 1114 913 0.0878 0.0615 0.8196 0.8621 4
Selumetinib C32 3.1600
uM
 48
hr
 1431 1172 0.1260 0.1270 0.8190 0.8303 3
Selumetinib C32 3.1600
uM
 48
hr
 1702 1393 0.1504 0.1270 0.8185 0.8303 4
Selumetinib C32 1.0000
uM
 72
hr
 1001 816 0.0808 0.1124 0.8152 0.7591 1
PLX-4720 C32 3.1600
uM
 48
hr
 1321 1073 0.1207 0.1550 0.8123 0.7840 2
PLX-4720 C32 3.1600
uM
 48
hr
 1504 1209 0.1435 0.1550 0.8039 0.7840 1
AZ-628 WM-115 3.1600
uM
 72
hr
 1520 1204 0.1042 0.0874 0.7921 0.8202 3
AZ-628 WM-115 3.1600
uM
 72
hr
 1633 1278 0.1171 0.0874 0.7826 0.8202 4
Selumetinib C32 1.0000
uM
 72
hr
 978 755 0.0974 0.1124 0.7720 0.7591 3
PLX-4720 C32 3.1600
uM
 72
hr
 820 631 0.0825 0.0669 0.7695 0.8134 2
PLX-4720 C32 3.1600
uM
 48
hr
 1443 1101 0.1664 0.1550 0.7630 0.7840 3
Vemurafenib COLO 858 3.1600
uM
 72
hr
 1176 892 0.1032 0.1269 0.7585 0.7234 2
PLX-4720 C32 3.1600
uM
 48
hr
 1599 1210 0.1893 0.1550 0.7567 0.7840 4
Selumetinib C32 1.0000
uM
 72
hr
 1071 807 0.1153 0.1124 0.7535 0.7591 2
AZ-628 WM-115 1.0000
uM
 72
hr
 1455 1092 0.1197 0.1723 0.7505 0.6442 2
PLX-4720 C32 3.1600
uM
 72
hr
 778 581 0.0860 0.0669 0.7468 0.8134 4
Vemurafenib COLO 858 3.1600
uM
 72
hr
 1205 867 0.1228 0.1269 0.7195 0.7234 1