Viability and apoptosis in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20217)
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| Small Molecule | Cell Line | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Total Number of Cells (Nuclei) | Number of Apoptotic Cells | Relative Viability | Mean Relative Viability | Apoptosis Fraction | Mean Apoptosis Fraction | Replicate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PLX-4720 | C32 | 3.1600 | uM | 24 | hr | 1702 | 481 | 0.7059 | 0.6928 | 0.2826 | 0.2905 | 4 |
| PLX-4720 | LOXIMVI | 3.1600 | uM | 72 | hr | 1420 | 0.6168 | 0.9994 | 0.2789 | 0.1595 | 3 | |
| Vemurafenib | K2 | 3.1600 | uM | 48 | hr | 1144 | 318 | 0.3014 | 0.4906 | 0.2780 | 0.2367 | 3 |
| SB590885 | C32 | 0.3160 | uM | 72 | hr | 1376 | 382 | 0.4340 | 0.4360 | 0.2776 | 0.2745 | 2 |
| AZ-628 | C32 | 0.3160 | uM | 24 | hr | 2238 | 618 | 0.9366 | 0.8698 | 0.2761 | 0.2799 | 2 |
| Selumetinib | COLO 858 | 1.0000 | uM | 48 | hr | 2243 | 619 | 0.3711 | 0.3740 | 0.2760 | 0.2319 | 3 |
| Vemurafenib | MMAC-SF | 1.0000 | uM | 72 | hr | 1336 | 368 | 0.2816 | 0.2904 | 0.2755 | 0.2648 | 1 |
| PLX-4720 | C32 | 1.0000 | uM | 24 | hr | 1949 | 537 | 0.8164 | 0.8236 | 0.2755 | 0.2452 | 2 |
| AZ-628 | MZ7-mel | 1.0000 | uM | 72 | hr | 1454 | 398 | 0.4399 | 0.3558 | 0.2737 | 0.2647 | 4 |
| SB590885 | C32 | 0.3160 | uM | 72 | hr | 1465 | 401 | 0.4646 | 0.4360 | 0.2737 | 0.2745 | 4 |
| SB590885 | C32 | 3.1600 | uM | 24 | hr | 1790 | 490 | 0.7516 | 0.7788 | 0.2737 | 0.2708 | 4 |
| PLX-4720 | COLO 858 | 3.1600 | uM | 48 | hr | 1860 | 509 | 0.3087 | 0.3057 | 0.2737 | 0.3229 | 1 |
| SB590885 | C32 | 3.1600 | uM | 24 | hr | 1858 | 507 | 0.7811 | 0.7788 | 0.2729 | 0.2708 | 1 |
| SB590885 | C32 | 3.1600 | uM | 24 | hr | 1897 | 517 | 0.7979 | 0.7788 | 0.2725 | 0.2708 | 2 |
| AZ-628 | WM-115 | 1.0000 | uM | 48 | hr | 508 | 138 | 0.7470 | 0.6582 | 0.2717 | 0.3114 | 1 |
| AZ-628 | MMAC-SF | 3.1600 | uM | 48 | hr | 2656 | 721 | 0.5101 | 0.5172 | 0.2715 | 0.2496 | 4 |
| AZ-628 | K2 | 1.0000 | uM | 48 | hr | 1290 | 350 | 0.3431 | 0.5963 | 0.2713 | 0.2538 | 3 |
| Selumetinib | WM-115 | 1.0000 | uM | 72 | hr | 1850 | 501 | 0.4450 | 0.4086 | 0.2708 | 0.3021 | 4 |
| LOXIMVI | 0.0000 | uM | 72 | hr | 2207 | 0.9697 | 0.2705 | 1 | ||||
| Selumetinib | COLO 858 | 1.0000 | uM | 72 | hr | 1235 | 331 | 0.3284 | 0.3419 | 0.2680 | 0.2586 | 1 |
| Selumetinib | MMAC-SF | 3.1600 | uM | 48 | hr | 2840 | 761 | 0.5481 | 0.5325 | 0.2680 | 0.2315 | 3 |
| SB590885 | LOXIMVI | 0.0032 | uM | 48 | hr | 1461 | 0.7194 | 0.9624 | 0.2676 | 0.1426 | 4 | |
| Vemurafenib | COLO 858 | 1.0000 | uM | 72 | hr | 1660 | 441 | 0.4428 | 0.3928 | 0.2657 | 0.2502 | 3 |
| Selumetinib | SKMEL28 | 3.1600 | uM | 72 | hr | 471 | 125 | 0.2595 | 0.3372 | 0.2654 | 0.2145 | 1 |
| Selumetinib | COLO 858 | 1.0000 | uM | 48 | hr | 2321 | 616 | 0.3896 | 0.3740 | 0.2654 | 0.2319 | 4 |