Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Dactolisib | MCF 10A | 0 (control) | 24 | hr | 351.94 | 125.18 | p-Akt | 50.36 | | |
| Dactolisib | MCF 10A | 0 (control) | 24 | hr | 316.42 | 141.54 | p-4EBP1 | 357.38 | | |
| Gefitinib | T47D | 0 (control) | 6 | hr | 187.68 | 101.38 | p-4EBP1 | 462.97 | | |
| Dactolisib | AU565 | 0 (control) | 6 | hr | 218.03 | 53.42 | p-4EBP1 | 64.33 | | |
| GSK1059615 | HCC1954 | 0 (control) | 24 | hr | 360.97 | 111.76 | p-S6 | 338.33 | | |
| Dactolisib | HCC1954 | 0 (control) | 6 | hr | 182.67 | 48.86 | p-S6 | 100.01 | | |
| Triciribine | MCF 10A | 0 (control) | 6 | hr | 446.41 | 161.85 | p-S6 | 482.53 | | |
| Dactolisib | AU565 | 0 (control) | 24 | hr | 529.58 | 125.56 | p-S6 | 517.92 | | |
| Triciribine | T47D | 0 (control) | 24 | hr | 156.16 | 103.29 | p-4EBP1 | 393.33 | | |
| Gefitinib | HCC1954 | 0 (control) | 6 | hr | 203.63 | 52.10 | p-S6 | 78.68 | | |
| Dactolisib | T47D | 0 (control) | 6 | hr | 102.03 | 45.53 | p-4EBP1 | 121.29 | | |
| Dactolisib | MCF 10A | 0 (control) | 6 | hr | 436.72 | 165.98 | p-Akt | 55.27 | | |
| Dactolisib | AU565 | 0 (control) | 6 | hr | 246.18 | 58.17 | p-S6 | 130.86 | | |
| Gefitinib | HCC1954 | 0 (control) | 24 | hr | 306.31 | 118.13 | p-S6 | 303.02 | | |
| MK2206 | T47D | 0 (control) | 24 | hr | 168.35 | 111.49 | p-4EBP1 | 409.81 | | |
| MK2206 | AU565 | 0 (control) | 24 | hr | 458.85 | 128.23 | p-S6 | 525.22 | | |
| Triciribine | AU565 | 0 (control) | 6 | hr | 344.99 | 87.13 | p-S6 | 242.25 | | |
| Triciribine | MCF 10A | 0 (control) | 24 | hr | 333.49 | 112.55 | p-Akt | 47.91 | | |
| GSK1059615 | AU565 | 0 (control) | 24 | hr | 451.46 | 118.58 | p-S6 | 522.55 | | |
| GSK1059615 | HCC1954 | 0 (control) | 6 | hr | 337.11 | 90.46 | p-4EBP1 | 107.99 | | |
| MK2206 | HCC1954 | 0 (control) | 6 | hr | 142.39 | 29.98 | p-4EBP1 | 49.89 | | |
| MK2206 | AU565 | 0 (control) | 6 | hr | 277.65 | 78.69 | p-S6 | 159.10 | | |
| Triciribine | AU565 | 0 (control) | 24 | hr | 513.50 | 123.82 | p-S6 | 483.08 | | |
| Torkinib | HCC1954 | 0 (control) | 6 | hr | 198.88 | 47.14 | p-S6 | 108.01 | | |
| Dactolisib | AU565 | 0 (control) | 6 | hr | 223.15 | 50.37 | p-4EBP1 | 55.92 | |