Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Torkinib | MCF 10A | 0 (control) | 6 | hr | 498.87 | 147.67 | p-Akt | 54.88 | | |
| MK2206 | AU565 | 0 (control) | 6 | hr | 215.16 | 63.34 | p-Akt | 22.81 | | |
| GSK1059615 | MCF 10A | 0 (control) | 6 | hr | 450.57 | 164.32 | p-Akt | 55.84 | | |
| Torkinib | HCC1954 | 0 (control) | 6 | hr | 182.67 | 40.88 | p-Akt | 23.74 | | |
| MK2206 | MCF 10A | 0 (control) | 6 | hr | 475.25 | 162.73 | p-Akt | 59.87 | | |
| Gefitinib | AU565 | 0 (control) | 6 | hr | 286.03 | 62.73 | p-Akt | 29.07 | | |
| Triciribine | MCF 10A | 0 (control) | 6 | hr | 477.54 | 163.37 | p-Akt | 60.15 | | |
| GSK1059615 | HCC1954 | 0 (control) | 6 | hr | 241.24 | 67.17 | p-Akt | 30.76 | | |
| Dactolisib | MCF 10A | 0 (control) | 6 | hr | 436.72 | 165.98 | p-Akt | 55.27 | | |
| Triciribine | AU565 | 0 (control) | 6 | hr | 231.71 | 61.01 | p-Akt | 21.54 | | |
| Gefitinib | T47D | 0 (control) | 6 | hr | 176.65 | 97.90 | p-Akt | 103.18 | | |
| MK2206 | HCC1954 | 0 (control) | 6 | hr | 271.78 | 84.99 | p-Akt | 42.06 | | |
| Torkinib | T47D | 0 (control) | 6 | hr | 192.56 | 91.57 | p-Akt | 104.03 | | |
| GSK1059615 | AU565 | 0 (control) | 6 | hr | 264.31 | 61.82 | p-Akt | 28.75 | | |
| GSK1059615 | T47D | 0 (control) | 6 | hr | 168.92 | 88.95 | p-Akt | 95.10 | | |
| Triciribine | HCC1954 | 0 (control) | 6 | hr | 225.27 | 70.45 | p-Akt | 36.85 | | |
| MK2206 | T47D | 0 (control) | 6 | hr | 102.66 | 35.62 | p-Akt | 15.31 | | |
| Dactolisib | AU565 | 0 (control) | 6 | hr | 235.49 | 54.01 | p-Akt | 23.90 | | |
| Triciribine | T47D | 0 (control) | 6 | hr | 109.11 | 47.87 | p-Akt | 21.01 | | |
| Dactolisib | HCC1954 | 0 (control) | 6 | hr | 262.96 | 93.99 | p-Akt | 56.53 | | |
| Dactolisib | T47D | 0 (control) | 6 | hr | 99.23 | 26.75 | p-Akt | 14.05 | | |
| Torkinib | AU565 | 0 (control) | 6 | hr | 228.66 | 55.93 | p-Akt | 26.38 | | |
| Gefitinib | AU565 | 1.0 | nM | 6 | hr | 297.48 | 65.22 | p-Akt | 31.78 | |
| Gefitinib | MCF 10A | 0 (control) | 6 | hr | 488.10 | 165.19 | p-Akt | 54.11 | | |
| Torkinib | AU565 | 0.422 | nM | 6 | hr | 269.85 | 59.34 | p-Akt | 25.74 | |