Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)

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Small Molecule Cell Line Drug Concentration Conc Units Timepoint Timepoint Units Measured pERK (Alexa 488) Measured p-Rb (Alexa 568) Alexa Fluor 647 Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) Image
Gefitinib T47D
100.0
nM
 6
hr
 165.65 99.07
p-Akt
 102.82 image if available
MK2206 T47D
3.16
nM
 6
hr
 101.19 50.29
p-Akt
 14.05 image if available
Torkinib T47D
31.6
nM
 6
hr
 157.45 81.63
p-Akt
 32.89 image if available
Dactolisib MCF 10A
0 (control)
 6
hr
 436.72 165.98
p-Akt
 55.27 image if available
GSK1059615 T47D
100.0
nM
 6
hr
 158.85 79.78
p-Akt
 56.09 image if available
Triciribine T47D
3.16
nM
 6
hr
 96.97 52.42
p-Akt
 20.09 image if available
MK2206 T47D
100.0
nM
 6
hr
 95.92 42.78
p-Akt
 7.64 image if available
Dactolisib HCC1954
1.0
nM
 6
hr
 151.35 38.59
p-Akt
 20.04 image if available
Triciribine T47D
100.0
nM
 6
hr
 113.51 61.24
p-Akt
 15.00 image if available
Dactolisib T47D
3.16
nM
 6
hr
 112.31 65.77
p-Akt
 19.14 image if available
Dactolisib T47D
100.0
nM
 6
hr
 101.93 53.36
p-Akt
 8.50 image if available
Triciribine AU565
0 (control)
 6
hr
 231.71 61.01
p-Akt
 21.54 image if available
Gefitinib AU565
316.0
nM
 6
hr
 234.01 54.85
p-Akt
 22.11 image if available
Gefitinib AU565
10.0
nM
 6
hr
 241.48 51.68
p-Akt
 25.73 image if available
Torkinib AU565
133.0
nM
 6
hr
 314.14 57.99
p-Akt
 14.98 image if available
Gefitinib MCF 10A
1.0
nM
 6
hr
 434.84 165.60
p-Akt
 49.10 image if available
GSK1059615 AU565
316.0
nM
 6
hr
 232.75 48.96
p-Akt
 23.52 image if available
Torkinib AU565
1.78
nM
 6
hr
 231.62 48.81
p-Akt
 18.34 image if available
MK2206 AU565
316.0
nM
 6
hr
 266.67 61.68
p-Akt
 13.97 image if available
Gefitinib T47D
0 (control)
 6
hr
 176.65 97.90
p-Akt
 103.18 image if available
Triciribine AU565
316.0
nM
 6
hr
 344.20 83.25
p-Akt
 21.62 image if available
GSK1059615 AU565
10.0
nM
 6
hr
 218.56 55.54
p-Akt
 24.76 image if available
Dactolisib AU565
316.0
nM
 6
hr
 300.22 59.06
p-Akt
 16.85 image if available
Torkinib MCF 10A
0.1
nM
 6
hr
 458.56 155.16
p-Akt
 49.17 image if available
Dactolisib HCC1954
3.16
nM
 6
hr
 156.03 43.22
p-4EBP1
 57.72 image if available