Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
Download: Excel (XLSX), Comma-separated (CSV)
| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| GSK1059615 | T47D | 3.16 | uM | 24 | hr | 216.74 | 68.63 | p-S6 | 9.16 | |
| Triciribine | HCC1954 | 31.6 | nM | 24 | hr | 283.10 | 118.84 | p-4EBP1 | 123.98 | |
| MK2206 | T47D | 3.16 | uM | 24 | hr | 148.11 | 44.41 | p-S6 | 20.30 | |
| Dactolisib | AU565 | 3.16 | nM | 24 | hr | 452.52 | 107.67 | p-S6 | 260.74 | |
| Triciribine | T47D | 3.16 | uM | 24 | hr | 166.45 | 79.85 | p-S6 | 460.62 | |
| Dactolisib | HCC1954 | 31.6 | nM | 24 | hr | 258.30 | 89.82 | p-4EBP1 | 37.14 | |
| Dactolisib | T47D | 3.16 | uM | 24 | hr | 125.73 | 47.33 | p-S6 | 5.11 | |
| Torkinib | AU565 | 2.37 | uM | 24 | hr | 400.68 | 59.69 | p-S6 | 10.43 | |
| Gefitinib | AU565 | 10.0 | uM | 24 | hr | 351.75 | 76.74 | p-S6 | 12.88 | |
| Gefitinib | MCF 10A | 31.6 | nM | 24 | hr | 296.01 | 168.37 | p-4EBP1 | 199.27 | |
| Torkinib | AU565 | 10.0 | uM | 24 | hr | 403.84 | 68.50 | p-S6 | 8.41 | |
| Gefitinib | HCC1954 | 3.16 | nM | 24 | hr | 281.78 | 127.34 | p-S6 | 326.53 | |
| GSK1059615 | AU565 | 10.0 | uM | 24 | hr | 312.25 | 74.93 | p-S6 | 9.63 | |
| Torkinib | MCF 10A | 7.5 | nM | 24 | hr | 392.70 | 173.87 | p-4EBP1 | 178.68 | |
| MK2206 | AU565 | 10.0 | uM | 24 | hr | 329.89 | 68.72 | p-S6 | 56.74 | |
| MK2206 | AU565 | 316.0 | nM | 24 | hr | 368.36 | 83.55 | p-S6 | 175.01 | |
| Triciribine | AU565 | 10.0 | uM | 24 | hr | 446.15 | 70.49 | p-S6 | 113.45 | |
| GSK1059615 | MCF 10A | 31.6 | nM | 24 | hr | 325.92 | 153.57 | p-4EBP1 | 239.72 | |
| Dactolisib | AU565 | 10.0 | uM | 24 | hr | 465.12 | 65.11 | p-S6 | 11.59 | |
| Torkinib | HCC1954 | 0.422 | nM | 24 | hr | 277.40 | 106.98 | p-S6 | 408.00 | |
| Gefitinib | HCC1954 | 10.0 | uM | 24 | hr | 258.13 | 76.63 | p-S6 | 386.78 | |
| MK2206 | MCF 10A | 31.6 | nM | 24 | hr | 272.79 | 163.64 | p-4EBP1 | 208.49 | |
| Torkinib | HCC1954 | 10.0 | uM | 24 | hr | 237.78 | 57.82 | p-S6 | 7.72 | |
| Gefitinib | MCF 10A | 10.0 | uM | 24 | hr | 173.33 | 27.59 | p-S6 | 20.83 | |
| GSK1059615 | HCC1954 | 10.0 | uM | 24 | hr | 304.57 | 57.47 | p-S6 | 10.22 | |