Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)

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Small Molecule Cell Line Drug Concentration Conc Units Timepoint Timepoint Units Measured pERK (Alexa 488) Measured p-Rb (Alexa 568) Alexa Fluor 647 Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) Image
Torkinib HCC1954
0.1
nM
 6
hr
 195.86 37.51
p-Akt
 23.03 image if available
Gefitinib HCC1954
100.0
nM
 6
hr
 166.09 41.51
p-Akt
 23.50 image if available
MK2206 MCF 10A
3.16
nM
 6
hr
 401.94 154.74
p-Akt
 43.87 image if available
Torkinib HCC1954
31.6
nM
 6
hr
 150.07 28.76
p-Akt
 14.38 image if available
Gefitinib AU565
0 (control)
 6
hr
 286.03 62.73
p-Akt
 29.07 image if available
GSK1059615 HCC1954
100.0
nM
 6
hr
 324.83 87.89
p-Akt
 34.01 image if available
Triciribine MCF 10A
3.16
nM
 6
hr
 404.45 155.90
p-Akt
 44.15 image if available
MK2206 HCC1954
100.0
nM
 6
hr
 239.59 77.83
p-Akt
 17.44 image if available
GSK1059615 HCC1954
1.0
nM
 6
hr
 251.93 70.14
p-Akt
 31.99 image if available
Triciribine HCC1954
100.0
nM
 6
hr
 200.10 73.80
p-Akt
 29.38 image if available
Dactolisib MCF 10A
3.16
nM
 6
hr
 394.32 173.00
p-Akt
 43.59 image if available
Dactolisib HCC1954
100.0
nM
 6
hr
 186.97 55.42
p-Akt
 16.95 image if available
Triciribine MCF 10A
0 (control)
 6
hr
 477.54 163.37
p-Akt
 60.15 image if available
Gefitinib MCF 10A
100.0
nM
 6
hr
 345.12 168.30
p-Akt
 37.38 image if available
Gefitinib T47D
3.16
nM
 6
hr
 181.54 100.89
p-Akt
 103.21 image if available
Torkinib MCF 10A
31.6
nM
 6
hr
 436.07 147.11
p-Akt
 29.06 image if available
MK2206 HCC1954
1.0
nM
 6
hr
 158.33 45.19
p-Akt
 18.61 image if available
GSK1059615 MCF 10A
100.0
nM
 6
hr
 316.39 158.33
p-Akt
 27.50 image if available
Torkinib T47D
0.422
nM
 6
hr
 170.81 90.25
p-Akt
 78.90 image if available
MK2206 MCF 10A
100.0
nM
 6
hr
 358.46 151.32
p-Akt
 25.55 image if available
GSK1059615 HCC1954
0 (control)
 6
hr
 241.24 67.17
p-Akt
 30.76 image if available
Triciribine MCF 10A
100.0
nM
 6
hr
 360.87 152.35
p-Akt
 25.66 image if available
GSK1059615 T47D
3.16
nM
 6
hr
 165.75 87.48
p-Akt
 92.56 image if available
Dactolisib MCF 10A
100.0
nM
 6
hr
 342.01 143.79
p-Akt
 24.33 image if available
Triciribine HCC1954
1.0
nM
 6
hr
 235.54 85.78
p-4EBP1
 104.82 image if available