HMS LINCS Project

Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)

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Small molecules	Cells
10057:MK2206 10098:Gefitinib 10172:GSK1059615 10232:Dactolisib 10280:Triciribine 10345:Torkinib	50091:AU565 50213:HCC1954 50541:T47D 50583:MCF 10A

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Small Molecule	Cell Line	Drug Concentration	Conc Units	Timepoint	Timepoint Units	Measured pERK (Alexa 488)	Measured p-Rb (Alexa 568)	Alexa Fluor 647	Measured p-Akt/p-4EBP1/p-S6 (Alexa 647)	Image
Triciribine	MCF 10A	31.6	nM	24	hr	252.91	139.46	p-S6	210.61
GSK1059615	HCC1954	3.16	nM	24	hr	281.50	119.97	p-4EBP1	138.63
Dactolisib	MCF 10A	31.6	nM	24	hr	270.07	139.60	p-S6	250.53
Triciribine	AU565	1.0	nM	24	hr	492.44	120.88	p-S6	499.19
Gefitinib	T47D	31.6	nM	24	hr	151.85	119.39	p-S6	339.11
MK2206	HCC1954	3.16	nM	24	hr	297.19	127.29	p-4EBP1	144.76
Torkinib	T47D	7.5	nM	24	hr	139.90	103.43	p-S6	294.61
GSK1059615	MCF 10A	100.0	nM	24	hr	401.51	187.40	p-S6	583.76
GSK1059615	T47D	31.6	nM	24	hr	174.61	103.71	p-S6	326.67
Triciribine	HCC1954	3.16	nM	24	hr	319.70	121.37	p-4EBP1	131.18
MK2206	T47D	31.6	nM	24	hr	143.74	105.54	p-S6	421.24
Dactolisib	AU565	1.0	nM	24	hr	488.73	114.80	p-S6	399.68
Triciribine	T47D	31.6	nM	24	hr	169.86	105.29	p-S6	392.27
Dactolisib	HCC1954	3.16	nM	24	hr	280.64	118.51	p-4EBP1	139.15
Dactolisib	T47D	31.6	nM	24	hr	124.69	58.78	p-S6	12.06
Torkinib	T47D	562.0	nM	24	hr	127.25	39.63	p-S6	5.53
Gefitinib	AU565	100.0	nM	24	hr	494.19	112.43	p-S6	486.83
Gefitinib	MCF 10A	3.16	nM	24	hr	318.35	167.30	p-4EBP1	230.98
Torkinib	AU565	31.6	nM	24	hr	427.57	74.48	p-S6	39.34
Gefitinib	HCC1954	1.0	nM	24	hr	307.64	120.90	p-S6	348.20
GSK1059615	AU565	100.0	nM	24	hr	479.81	110.27	p-S6	446.19
Torkinib	MCF 10A	0.422	nM	24	hr	359.78	160.84	p-4EBP1	247.62
MK2206	AU565	100.0	nM	24	hr	378.47	105.02	p-S6	348.62
MK2206	MCF 10A	100.0	nM	24	hr	285.48	156.23	p-S6	281.30
Triciribine	AU565	100.0	nM	24	hr	594.21	121.58	p-S6	442.44

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