Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
Download: Excel (XLSX), Comma-separated (CSV)
| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Triciribine | AU565 | 31.6 | nM | 6 | hr | 349.86 | 83.99 | p-4EBP1 | 125.84 | |
| Triciribine | AU565 | 31.6 | nM | 24 | hr | 499.46 | 124.57 | p-4EBP1 | 196.58 | |
| Triciribine | HCC1954 | 1.0 | nM | 24 | hr | 303.58 | 117.35 | p-4EBP1 | 135.97 | |
| Triciribine | HCC1954 | 1.0 | nM | 6 | hr | 235.54 | 85.78 | p-4EBP1 | 104.82 | |
| Triciribine | HCC1954 | 1.0 | nM | 6 | hr | 251.09 | 80.77 | p-Akt | 44.35 | |
| Triciribine | AU565 | 1.0 | nM | 6 | hr | 225.05 | 59.35 | p-Akt | 21.63 | |
| Triciribine | T47D | 3.16 | nM | 24 | hr | 152.67 | 103.52 | p-S6 | 378.65 | |
| Triciribine | HCC1954 | 10.0 | nM | 24 | hr | 292.05 | 110.86 | p-S6 | 291.89 | |
| Triciribine | AU565 | 1.0 | nM | 24 | hr | 484.33 | 118.39 | p-Akt | 103.66 | |
| Triciribine | AU565 | 1.0 | uM | 6 | hr | 295.69 | 71.82 | p-Akt | 19.96 | |
| Triciribine | AU565 | 1.0 | uM | 24 | hr | 442.50 | 77.06 | p-Akt | 37.03 | |
| Triciribine | AU565 | 1.0 | nM | 24 | hr | 545.03 | 125.22 | p-Akt | 105.22 | |
| Triciribine | HCC1954 | 31.6 | nM | 6 | hr | 250.28 | 91.52 | p-4EBP1 | 117.60 | |
| Triciribine | HCC1954 | 31.6 | nM | 24 | hr | 268.23 | 117.03 | p-4EBP1 | 128.35 | |
| Triciribine | AU565 | 1.0 | nM | 6 | hr | 382.75 | 90.73 | p-Akt | 30.89 | |
| Triciribine | AU565 | 100.0 | nM | 24 | hr | 501.15 | 109.40 | p-S6 | 392.84 | |
| Triciribine | HCC1954 | 3.16 | nM | 6 | hr | 165.07 | 56.66 | p-S6 | 125.32 | |
| Triciribine | HCC1954 | 3.16 | nM | 24 | hr | 300.37 | 110.91 | p-S6 | 306.04 | |
| Triciribine | MCF 10A | 10.0 | uM | 6 | hr | 353.36 | 139.24 | p-4EBP1 | 315.88 | |
| Triciribine | T47D | 3.16 | nM | 6 | hr | 108.85 | 68.27 | p-S6 | 121.84 | |
| Triciribine | AU565 | 100.0 | nM | 6 | hr | 300.85 | 74.06 | p-S6 | 185.54 | |
| Triciribine | T47D | 0 (control) | 24 | hr | 176.48 | 88.36 | p-Akt | 66.59 | | |
| Triciribine | T47D | 0 (control) | 6 | hr | 98.11 | 30.56 | p-Akt | 14.84 | | |
| Triciribine | MCF 10A | 0 (control) | 24 | hr | 301.15 | 117.66 | p-Akt | 45.04 | | |
| Triciribine | MCF 10A | 31.6 | nM | 6 | hr | 379.12 | 156.82 | p-4EBP1 | 360.76 | |