Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)

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Small Molecule Cell Line Drug Concentration Conc Units Timepoint Timepoint Units Measured pERK (Alexa 488) Measured p-Rb (Alexa 568) Alexa Fluor 647 Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) Image
Dactolisib T47D
1.0
nM
 6
hr
 90.24 35.16
p-Akt
 13.70 image if available
Dactolisib T47D
1.0
uM
 6
hr
 90.30 37.28
p-Akt
 6.14 image if available
Dactolisib T47D
31.6
nM
 6
hr
 90.45 41.37
p-4EBP1
 104.60 image if available
Dactolisib T47D
3.16
nM
 6
hr
 90.48 33.02
p-4EBP1
 89.29 image if available
MK2206 T47D
10.0
nM
 6
hr
 91.10 36.69
p-4EBP1
 83.19 image if available
MK2206 T47D
10.0
nM
 6
hr
 91.29 31.15
p-4EBP1
 65.25 image if available
MK2206 T47D
0 (control)
 6
hr
 91.40 33.14
p-S6
 37.61 image if available
Dactolisib T47D
316.0
nM
 6
hr
 91.80 41.44
p-S6
 3.90 image if available
Triciribine T47D
0 (control)
 6
hr
 91.82 35.81
p-4EBP1
 108.61 image if available
MK2206 T47D
31.6
nM
 6
hr
 91.91 38.77
p-S6
 39.68 image if available
Dactolisib T47D
1.0
nM
 6
hr
 92.26 27.93
p-4EBP1
 75.18 image if available
Dactolisib T47D
316.0
nM
 6
hr
 92.43 45.00
p-Akt
 6.96 image if available
Dactolisib T47D
1.0
nM
 6
hr
 92.87 40.61
p-S6
 46.08 image if available
Dactolisib T47D
1.0
nM
 6
hr
 92.92 41.52
p-Akt
 14.33 image if available
MK2206 T47D
3.16
nM
 6
hr
 93.03 33.88
p-S6
 37.58 image if available
MK2206 T47D
100.0
nM
 6
hr
 93.04 34.39
p-4EBP1
 75.18 image if available
Dactolisib T47D
10.0
uM
 6
hr
 93.15 46.29
p-Akt
 6.63 image if available
MK2206 T47D
0 (control)
 6
hr
 93.24 32.03
p-S6
 42.80 image if available
MK2206 T47D
3.16
nM
 6
hr
 93.38 33.38
p-4EBP1
 75.21 image if available
MK2206 T47D
0 (control)
 6
hr
 93.47 32.94
p-Akt
 14.46 image if available
Dactolisib T47D
0 (control)
 6
hr
 93.59 40.79
p-Akt
 16.04 image if available
Dactolisib T47D
10.0
nM
 6
hr
 93.60 47.20
p-4EBP1
 138.33 image if available
Triciribine T47D
0 (control)
 6
hr
 93.67 36.69
p-S6
 48.97 image if available
Dactolisib T47D
1.0
uM
 6
hr
 93.74 42.44
p-Akt
 6.74 image if available
Dactolisib T47D
1.0
uM
 6
hr
 93.77 37.06
p-S6
 3.89 image if available