Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| MK2206 | T47D | 100.0 | nM | 24 | hr | 136.91 | 80.20 | p-4EBP1 | 327.21 | |
| Gefitinib | T47D | 3.16 | uM | 24 | hr | 137.19 | 93.74 | p-4EBP1 | 367.13 | |
| Gefitinib | T47D | 3.16 | uM | 24 | hr | 137.24 | 97.28 | p-4EBP1 | 368.05 | |
| Torkinib | T47D | 10.0 | uM | 24 | hr | 137.62 | 40.90 | p-Akt | 14.21 | |
| Dactolisib | T47D | 10.0 | uM | 24 | hr | 137.63 | 102.12 | p-S6 | 6.93 | |
| Gefitinib | T47D | 3.16 | uM | 24 | hr | 137.81 | 105.61 | p-Akt | 73.77 | |
| MK2206 | T47D | 100.0 | nM | 24 | hr | 137.94 | 84.66 | p-4EBP1 | 345.76 | |
| Dactolisib | T47D | 1.0 | nM | 24 | hr | 138.24 | 90.29 | p-Akt | 47.16 | |
| Dactolisib | T47D | 3.16 | nM | 24 | hr | 138.41 | 87.20 | p-Akt | 40.75 | |
| Gefitinib | HCC1954 | 3.16 | uM | 6 | hr | 138.54 | 52.42 | p-S6 | 83.69 | |
| MK2206 | T47D | 1.0 | uM | 24 | hr | 138.60 | 47.77 | p-Akt | 13.85 | |
| MK2206 | T47D | 316.0 | nM | 24 | hr | 138.70 | 57.11 | p-Akt | 16.15 | |
| Torkinib | T47D | 7.5 | nM | 24 | hr | 138.86 | 70.27 | p-Akt | 34.18 | |
| Gefitinib | T47D | 10.0 | uM | 24 | hr | 139.09 | 65.73 | p-Akt | 66.96 | |
| Dactolisib | T47D | 1.0 | nM | 24 | hr | 139.38 | 100.34 | p-4EBP1 | 323.20 | |
| Gefitinib | T47D | 316.0 | nM | 24 | hr | 139.46 | 104.96 | p-4EBP1 | 390.50 | |
| MK2206 | T47D | 3.16 | nM | 24 | hr | 139.77 | 99.87 | p-S6 | 356.63 | |
| MK2206 | T47D | 1.0 | uM | 24 | hr | 139.84 | 56.58 | p-4EBP1 | 292.80 | |
| Torkinib | T47D | 7.5 | nM | 24 | hr | 139.90 | 103.43 | p-S6 | 294.61 | |
| Dactolisib | T47D | 3.16 | nM | 24 | hr | 139.90 | 103.58 | p-4EBP1 | 334.60 | |
| Gefitinib | HCC1954 | 3.16 | uM | 6 | hr | 140.11 | 52.98 | p-4EBP1 | 71.75 | |
| Dactolisib | T47D | 10.0 | nM | 24 | hr | 140.23 | 84.77 | p-Akt | 33.74 | |
| Torkinib | T47D | 562.0 | nM | 6 | hr | 140.25 | 67.60 | p-S6 | 5.64 | |
| GSK1059615 | T47D | 100.0 | nM | 24 | hr | 140.32 | 80.90 | p-4EBP1 | 391.09 | |
| Gefitinib | T47D | 3.16 | uM | 24 | hr | 140.35 | 98.30 | p-S6 | 362.29 | |