Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Torkinib | MCF 10A | 2.37 | uM | 6 | hr | 625.54 | 171.57 | p-S6 | 556.27 | |
| Torkinib | MCF 10A | 2.37 | uM | 6 | hr | 630.91 | 159.45 | p-4EBP1 | 13.63 | |
| Gefitinib | AU565 | 1.0 | nM | 24 | hr | 634.91 | 132.12 | p-S6 | 494.50 | |
| Torkinib | MCF 10A | 10.0 | uM | 6 | hr | 642.36 | 156.71 | p-4EBP1 | 7.99 | |
| Gefitinib | AU565 | 0 (control) | 24 | hr | 659.08 | 130.41 | p-Akt | 134.35 | |