Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
Download: Excel (XLSX), Comma-separated (CSV)
| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Gefitinib | HCC1954 | 316.0 | nM | 6 | hr | 126.23 | 35.22 | p-Akt | 18.96 | |
| Gefitinib | HCC1954 | 3.16 | uM | 6 | hr | 127.13 | 37.66 | p-Akt | 19.29 | |
| Torkinib | T47D | 31.6 | nM | 24 | hr | 127.17 | 45.02 | p-Akt | 24.28 | |
| Torkinib | T47D | 562.0 | nM | 24 | hr | 127.25 | 39.63 | p-S6 | 5.53 | |
| Gefitinib | HCC1954 | 3.16 | uM | 6 | hr | 127.32 | 31.57 | p-4EBP1 | 45.85 | |
| Torkinib | T47D | 562.0 | nM | 24 | hr | 127.60 | 40.01 | p-Akt | 14.71 | |
| Dactolisib | T47D | 31.6 | nM | 24 | hr | 128.11 | 59.27 | p-4EBP1 | 215.44 | |
| Torkinib | T47D | 2.37 | uM | 24 | hr | 128.17 | 38.84 | p-Akt | 13.90 | |
| Gefitinib | HCC1954 | 1.0 | uM | 6 | hr | 128.30 | 38.07 | p-4EBP1 | 57.69 | |
| Gefitinib | HCC1954 | 3.16 | uM | 6 | hr | 128.34 | 30.50 | p-Akt | 19.47 | |
| Gefitinib | HCC1954 | 10.0 | uM | 6 | hr | 129.17 | 33.74 | p-4EBP1 | 53.39 | |
| MK2206 | T47D | 100.0 | nM | 24 | hr | 129.23 | 87.88 | p-S6 | 388.78 | |
| Dactolisib | T47D | 10.0 | nM | 24 | hr | 129.25 | 89.70 | p-4EBP1 | 315.12 | |
| Triciribine | T47D | 3.16 | uM | 6 | hr | 129.54 | 76.65 | p-S6 | 153.50 | |
| Torkinib | T47D | 10.0 | uM | 24 | hr | 129.60 | 43.22 | p-4EBP1 | 8.96 | |
| MK2206 | T47D | 1.0 | uM | 24 | hr | 130.30 | 53.57 | p-4EBP1 | 296.02 | |
| Dactolisib | T47D | 10.0 | nM | 24 | hr | 130.33 | 99.36 | p-S6 | 195.23 | |
| MK2206 | T47D | 316.0 | nM | 24 | hr | 130.59 | 62.14 | p-4EBP1 | 310.05 | |
| Dactolisib | T47D | 3.16 | nM | 24 | hr | 130.71 | 105.86 | p-4EBP1 | 330.99 | |
| MK2206 | T47D | 316.0 | nM | 24 | hr | 131.03 | 70.58 | p-4EBP1 | 321.88 | |
| Dactolisib | T47D | 3.16 | nM | 24 | hr | 131.38 | 94.63 | p-S6 | 269.12 | |
| Gefitinib | HCC1954 | 3.16 | nM | 6 | hr | 131.67 | 28.62 | p-4EBP1 | 36.83 | |
| Dactolisib | T47D | 10.0 | nM | 24 | hr | 132.09 | 76.49 | p-Akt | 31.82 | |
| Dactolisib | T47D | 3.16 | uM | 24 | hr | 132.13 | 45.78 | p-Akt | 14.01 | |
| Torkinib | T47D | 10.0 | uM | 24 | hr | 132.29 | 39.88 | p-S6 | 6.28 | |