Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Triciribine | T47D | 10.0 | uM | 6 | hr | 110.90 | 45.64 | p-Akt | 9.31 | |
| Gefitinib | AU565 | 100.0 | nM | 6 | hr | 215.94 | 45.64 | p-S6 | 67.64 | |
| Dactolisib | MCF 10A | 1.0 | uM | 24 | hr | 366.10 | 45.69 | p-Akt | 12.12 | |
| Dactolisib | T47D | 3.16 | uM | 6 | hr | 101.02 | 45.77 | p-4EBP1 | 5.42 | |
| Dactolisib | T47D | 3.16 | uM | 24 | hr | 132.13 | 45.78 | p-Akt | 14.01 | |
| Dactolisib | HCC1954 | 31.6 | nM | 6 | hr | 184.53 | 45.81 | p-Akt | 19.34 | |
| MK2206 | T47D | 31.6 | nM | 6 | hr | 99.94 | 45.83 | p-4EBP1 | 109.15 | |
| MK2206 | AU565 | 10.0 | nM | 6 | hr | 183.97 | 46.00 | p-Akt | 14.47 | |
| Triciribine | T47D | 1.0 | nM | 6 | hr | 99.51 | 46.00 | p-4EBP1 | 135.71 | |
| Triciribine | T47D | 1.0 | nM | 6 | hr | 98.69 | 46.05 | p-S6 | 45.90 | |
| Dactolisib | T47D | 316.0 | nM | 6 | hr | 97.57 | 46.09 | p-4EBP1 | 19.39 | |
| Triciribine | T47D | 316.0 | nM | 6 | hr | 109.57 | 46.13 | p-S6 | 50.30 | |
| Torkinib | HCC1954 | 0.422 | nM | 6 | hr | 213.03 | 46.19 | p-Akt | 24.57 | |
| GSK1059615 | AU565 | 3.16 | uM | 6 | hr | 203.42 | 46.27 | p-S6 | 7.86 | |
| MK2206 | T47D | 3.16 | uM | 24 | hr | 151.33 | 46.28 | p-S6 | 26.26 | |
| Dactolisib | T47D | 10.0 | uM | 6 | hr | 93.15 | 46.29 | p-Akt | 6.63 | |
| Dactolisib | AU565 | 10.0 | nM | 6 | hr | 210.20 | 46.30 | p-Akt | 19.17 | |
| Triciribine | T47D | 1.0 | nM | 6 | hr | 96.98 | 46.31 | p-Akt | 19.11 | |
| Triciribine | T47D | 1.0 | uM | 6 | hr | 107.64 | 46.32 | p-S6 | 53.44 | |
| MK2206 | T47D | 10.0 | nM | 6 | hr | 100.04 | 46.74 | p-Akt | 11.24 | |
| Dactolisib | T47D | 316.0 | nM | 6 | hr | 97.87 | 46.75 | p-S6 | 4.38 | |
| MK2206 | T47D | 3.16 | nM | 6 | hr | 98.37 | 46.79 | p-4EBP1 | 109.35 | |
| Dactolisib | HCC1954 | 1.0 | nM | 6 | hr | 167.72 | 46.85 | p-4EBP1 | 64.61 | |
| GSK1059615 | AU565 | 1.0 | uM | 6 | hr | 223.90 | 46.95 | p-S6 | 8.84 | |
| Dactolisib | AU565 | 1.0 | nM | 6 | hr | 202.47 | 47.00 | p-4EBP1 | 51.99 | |