Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Triciribine | MCF 10A | 3.16 | nM | 6 | hr | 389.81 | 156.34 | p-S6 | 538.30 | |
| MK2206 | MCF 10A | 100.0 | nM | 24 | hr | 273.76 | 156.36 | p-S6 | 238.51 | |
| Torkinib | MCF 10A | 133.0 | nM | 24 | hr | 438.54 | 156.39 | p-4EBP1 | 79.88 | |
| Gefitinib | MCF 10A | 10.0 | nM | 24 | hr | 269.57 | 156.39 | p-4EBP1 | 207.59 | |
| Triciribine | MCF 10A | 1.0 | nM | 6 | hr | 468.07 | 156.41 | p-4EBP1 | 394.50 | |
| Dactolisib | MCF 10A | 0 (control) | 6 | hr | 422.77 | 156.53 | p-Akt | 48.09 | | |
| MK2206 | MCF 10A | 31.6 | nM | 6 | hr | 385.30 | 156.59 | p-S6 | 445.48 | |
| Gefitinib | MCF 10A | 1.0 | nM | 24 | hr | 355.52 | 156.59 | p-S6 | 408.54 | |
| Triciribine | MCF 10A | 3.16 | nM | 24 | hr | 254.77 | 156.64 | p-4EBP1 | 238.19 | |
| Torkinib | MCF 10A | 10.0 | uM | 6 | hr | 642.36 | 156.71 | p-4EBP1 | 7.99 | |
| MK2206 | MCF 10A | 3.16 | uM | 24 | hr | 368.98 | 156.73 | p-S6 | 386.60 | |
| Torkinib | MCF 10A | 562.0 | nM | 6 | hr | 543.48 | 156.73 | p-S6 | 529.47 | |
| MK2206 | MCF 10A | 1.0 | nM | 6 | hr | 400.04 | 156.74 | p-S6 | 410.91 | |
| Triciribine | MCF 10A | 1.0 | nM | 6 | hr | 427.45 | 156.76 | p-S6 | 544.61 | |
| Triciribine | MCF 10A | 3.16 | uM | 6 | hr | 375.49 | 156.80 | p-S6 | 644.30 | |
| Triciribine | MCF 10A | 31.6 | nM | 6 | hr | 379.12 | 156.82 | p-4EBP1 | 360.76 | |
| Triciribine | MCF 10A | 1.0 | nM | 6 | hr | 401.41 | 156.95 | p-S6 | 411.77 | |
| Dactolisib | MCF 10A | 1.0 | nM | 6 | hr | 436.43 | 157.03 | p-Akt | 43.37 | |
| Torkinib | MCF 10A | 1.78 | nM | 6 | hr | 418.98 | 157.03 | p-Akt | 41.14 | |
| Triciribine | MCF 10A | 31.6 | nM | 6 | hr | 385.84 | 157.07 | p-S6 | 446.88 | |
| MK2206 | MCF 10A | 3.16 | nM | 6 | hr | 390.81 | 157.12 | p-4EBP1 | 361.22 | |
| MK2206 | MCF 10A | 316.0 | nM | 6 | hr | 402.65 | 157.16 | p-S6 | 488.56 | |
| GSK1059615 | MCF 10A | 31.6 | nM | 24 | hr | 290.16 | 157.18 | p-4EBP1 | 233.47 | |
| Gefitinib | MCF 10A | 316.0 | nM | 6 | hr | 239.67 | 157.19 | p-4EBP1 | 276.80 | |
| MK2206 | MCF 10A | 10.0 | nM | 6 | hr | 386.97 | 157.19 | p-4EBP1 | 348.64 | |