Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
Download: Excel (XLSX), Comma-separated (CSV)
| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Dactolisib | T47D | 3.16 | uM | 6 | hr | 86.04 | 36.41 | p-Akt | 6.31 | |
| Torkinib | T47D | 10.0 | uM | 6 | hr | 161.35 | 70.83 | p-S6 | 6.32 | |
| Dactolisib | MCF 10A | 10.0 | uM | 6 | hr | 286.54 | 126.04 | p-4EBP1 | 6.41 | |
| Dactolisib | T47D | 10.0 | uM | 6 | hr | 95.38 | 37.54 | p-Akt | 6.44 | |
| Dactolisib | T47D | 316.0 | nM | 6 | hr | 88.99 | 42.86 | p-Akt | 6.47 | |
| Torkinib | T47D | 133.0 | nM | 6 | hr | 150.60 | 73.38 | p-S6 | 6.52 | |
| Dactolisib | T47D | 100.0 | nM | 6 | hr | 84.56 | 34.41 | p-Akt | 6.52 | |
| MK2206 | T47D | 10.0 | uM | 6 | hr | 110.32 | 28.55 | p-Akt | 6.57 | |
| Dactolisib | T47D | 10.0 | uM | 6 | hr | 93.15 | 46.29 | p-Akt | 6.63 | |
| Dactolisib | MCF 10A | 3.16 | uM | 6 | hr | 283.91 | 122.02 | p-4EBP1 | 6.68 | |
| MK2206 | T47D | 100.0 | nM | 6 | hr | 97.74 | 36.32 | p-Akt | 6.68 | |
| Dactolisib | T47D | 10.0 | uM | 24 | hr | 142.42 | 100.03 | p-S6 | 6.69 | |
| GSK1059615 | HCC1954 | 1.0 | uM | 24 | hr | 253.56 | 53.10 | p-S6 | 6.70 | |
| GSK1059615 | MCF 10A | 10.0 | uM | 6 | hr | 223.02 | 132.43 | p-S6 | 6.72 | |
| Dactolisib | T47D | 1.0 | uM | 6 | hr | 93.74 | 42.44 | p-Akt | 6.74 | |
| GSK1059615 | T47D | 1.0 | uM | 6 | hr | 178.56 | 69.11 | p-S6 | 6.78 | |
| Dactolisib | T47D | 3.16 | uM | 6 | hr | 94.75 | 44.06 | p-Akt | 6.83 | |
| MK2206 | T47D | 10.0 | uM | 6 | hr | 118.02 | 33.64 | p-Akt | 6.86 | |
| GSK1059615 | MCF 10A | 10.0 | uM | 6 | hr | 202.33 | 118.30 | p-S6 | 6.93 | |
| Dactolisib | T47D | 10.0 | uM | 24 | hr | 137.63 | 102.12 | p-S6 | 6.93 | |
| Torkinib | T47D | 10.0 | uM | 24 | hr | 146.76 | 43.93 | p-S6 | 6.94 | |
| Dactolisib | T47D | 316.0 | nM | 6 | hr | 92.43 | 45.00 | p-Akt | 6.96 | |
| Torkinib | AU565 | 2.37 | uM | 6 | hr | 219.64 | 36.57 | p-4EBP1 | 7.15 | |
| Dactolisib | MCF 10A | 1.0 | uM | 6 | hr | 304.54 | 120.52 | p-4EBP1 | 7.16 | |
| MK2206 | T47D | 1.0 | uM | 6 | hr | 107.58 | 49.92 | p-Akt | 7.19 | |