Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Dactolisib | T47D | 316.0 | nM | 24 | hr | 110.55 | 38.49 | p-S6 | 5.52 | |
| Torkinib | T47D | 562.0 | nM | 24 | hr | 127.25 | 39.63 | p-S6 | 5.53 | |
| Torkinib | T47D | 562.0 | nM | 6 | hr | 140.25 | 67.60 | p-S6 | 5.64 | |
| Dactolisib | T47D | 3.16 | uM | 24 | hr | 125.24 | 44.30 | p-S6 | 5.70 | |
| GSK1059615 | T47D | 3.16 | uM | 6 | hr | 155.38 | 59.43 | p-S6 | 5.70 | |
| Dactolisib | T47D | 1.0 | uM | 6 | hr | 88.25 | 32.38 | p-4EBP1 | 5.74 | |
| Dactolisib | T47D | 100.0 | nM | 24 | hr | 116.78 | 40.97 | p-S6 | 5.80 | |
| Torkinib | T47D | 2.37 | uM | 6 | hr | 150.77 | 71.12 | p-S6 | 5.80 | |
| MK2206 | T47D | 3.16 | uM | 6 | hr | 102.31 | 29.14 | p-Akt | 5.87 | |
| MK2206 | T47D | 1.0 | uM | 6 | hr | 99.03 | 36.33 | p-Akt | 5.91 | |
| Dactolisib | T47D | 100.0 | nM | 24 | hr | 106.94 | 39.36 | p-S6 | 5.92 | |
| Torkinib | T47D | 133.0 | nM | 6 | hr | 157.46 | 75.31 | p-S6 | 5.95 | |
| GSK1059615 | T47D | 1.0 | uM | 6 | hr | 149.68 | 62.00 | p-S6 | 6.03 | |
| GSK1059615 | T47D | 3.16 | uM | 6 | hr | 178.81 | 63.98 | p-S6 | 6.03 | |
| Torkinib | T47D | 2.37 | uM | 6 | hr | 153.65 | 71.36 | p-S6 | 6.03 | |
| Torkinib | T47D | 10.0 | uM | 6 | hr | 150.92 | 73.37 | p-S6 | 6.07 | |
| Dactolisib | MCF 10A | 10.0 | uM | 6 | hr | 274.72 | 125.82 | p-4EBP1 | 6.11 | |
| Dactolisib | T47D | 1.0 | uM | 6 | hr | 90.30 | 37.28 | p-Akt | 6.14 | |
| Dactolisib | T47D | 1.0 | uM | 24 | hr | 114.47 | 37.15 | p-S6 | 6.15 | |
| MK2206 | T47D | 316.0 | nM | 6 | hr | 97.94 | 33.78 | p-Akt | 6.19 | |
| Torkinib | T47D | 10.0 | uM | 24 | hr | 132.29 | 39.88 | p-S6 | 6.28 | |
| Dactolisib | T47D | 1.0 | uM | 6 | hr | 88.97 | 38.37 | p-4EBP1 | 6.28 | |
| GSK1059615 | T47D | 1.0 | uM | 24 | hr | 157.48 | 47.97 | p-S6 | 6.29 | |
| Dactolisib | MCF 10A | 1.0 | uM | 24 | hr | 358.30 | 52.88 | p-4EBP1 | 6.29 | |
| Torkinib | T47D | 562.0 | nM | 6 | hr | 150.96 | 72.90 | p-S6 | 6.30 | |