Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
Download: Excel (XLSX), Comma-separated (CSV)
| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Torkinib | HCC1954 | 10.0 | uM | 24 | hr | 249.22 | 62.64 | p-4EBP1 | 12.82 | |
| Gefitinib | AU565 | 10.0 | uM | 24 | hr | 351.75 | 76.74 | p-S6 | 12.88 | |
| Torkinib | MCF 10A | 10.0 | uM | 24 | hr | 425.35 | 75.91 | p-Akt | 12.93 | |
| Torkinib | T47D | 31.6 | nM | 24 | hr | 132.90 | 53.60 | p-S6 | 13.00 | |
| Torkinib | MCF 10A | 2.37 | uM | 6 | hr | 612.51 | 140.42 | p-4EBP1 | 13.01 | |
| Dactolisib | T47D | 31.6 | nM | 24 | hr | 159.25 | 59.11 | p-S6 | 13.01 | |
| Torkinib | HCC1954 | 2.37 | uM | 6 | hr | 268.74 | 56.54 | p-Akt | 13.02 | |
| MK2206 | T47D | 1.0 | nM | 6 | hr | 94.42 | 35.53 | p-Akt | 13.06 | |
| Torkinib | MCF 10A | 562.0 | nM | 24 | hr | 427.65 | 97.49 | p-Akt | 13.14 | |
| Torkinib | AU565 | 10.0 | uM | 24 | hr | 402.80 | 73.30 | p-4EBP1 | 13.16 | |
| Torkinib | MCF 10A | 562.0 | nM | 24 | hr | 387.02 | 90.98 | p-Akt | 13.16 | |
| MK2206 | HCC1954 | 3.16 | uM | 6 | hr | 181.47 | 56.47 | p-Akt | 13.18 | |
| Dactolisib | HCC1954 | 100.0 | nM | 6 | hr | 216.92 | 70.29 | p-4EBP1 | 13.19 | |
| Dactolisib | AU565 | 316.0 | nM | 6 | hr | 268.71 | 58.81 | p-S6 | 13.22 | |
| Triciribine | T47D | 1.0 | uM | 6 | hr | 119.47 | 61.20 | p-Akt | 13.24 | |
| Torkinib | AU565 | 31.6 | nM | 6 | hr | 280.20 | 51.81 | p-S6 | 13.25 | |
| GSK1059615 | MCF 10A | 10.0 | uM | 24 | hr | 200.07 | 77.09 | p-Akt | 13.27 | |
| MK2206 | AU565 | 3.16 | uM | 6 | hr | 256.25 | 58.14 | p-Akt | 13.28 | |
| Dactolisib | HCC1954 | 100.0 | nM | 6 | hr | 201.86 | 59.83 | p-4EBP1 | 13.31 | |
| Torkinib | T47D | 2.37 | uM | 24 | hr | 125.67 | 44.17 | p-4EBP1 | 13.31 | |
| Dactolisib | AU565 | 316.0 | nM | 24 | hr | 439.09 | 68.21 | p-4EBP1 | 13.32 | |
| GSK1059615 | MCF 10A | 3.16 | uM | 24 | hr | 225.10 | 112.78 | p-S6 | 13.32 | |
| Dactolisib | T47D | 3.16 | uM | 24 | hr | 119.38 | 40.84 | p-Akt | 13.33 | |
| GSK1059615 | HCC1954 | 316.0 | nM | 24 | hr | 270.39 | 70.25 | p-S6 | 13.40 | |
| Dactolisib | T47D | 10.0 | nM | 6 | hr | 105.88 | 55.02 | p-Akt | 13.40 | |