Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| GSK1059615 | MCF 10A | 10.0 | uM | 24 | hr | 228.06 | 74.27 | p-S6 | 12.24 | |
| GSK1059615 | MCF 10A | 3.16 | uM | 24 | hr | 239.08 | 117.67 | p-S6 | 12.24 | |
| Torkinib | HCC1954 | 10.0 | uM | 6 | hr | 209.88 | 40.62 | p-Akt | 12.29 | |
| GSK1059615 | HCC1954 | 10.0 | uM | 6 | hr | 418.22 | 76.83 | p-4EBP1 | 12.32 | |
| Torkinib | AU565 | 133.0 | nM | 6 | hr | 273.77 | 50.73 | p-4EBP1 | 12.35 | |
| Torkinib | AU565 | 10.0 | uM | 6 | hr | 198.03 | 31.21 | p-Akt | 12.37 | |
| Torkinib | AU565 | 562.0 | nM | 24 | hr | 391.61 | 66.24 | p-4EBP1 | 12.45 | |
| Triciribine | T47D | 3.16 | uM | 6 | hr | 117.72 | 59.79 | p-Akt | 12.45 | |
| MK2206 | MCF 10A | 10.0 | uM | 24 | hr | 310.25 | 82.81 | p-Akt | 12.52 | |
| Dactolisib | T47D | 1.0 | uM | 24 | hr | 115.16 | 30.63 | p-Akt | 12.53 | |
| GSK1059615 | MCF 10A | 3.16 | uM | 6 | hr | 216.21 | 121.05 | p-S6 | 12.53 | |
| Dactolisib | HCC1954 | 316.0 | nM | 6 | hr | 193.59 | 49.84 | p-Akt | 12.54 | |
| GSK1059615 | MCF 10A | 3.16 | uM | 6 | hr | 252.13 | 124.95 | p-S6 | 12.57 | |
| Dactolisib | AU565 | 3.16 | uM | 24 | hr | 496.60 | 68.46 | p-S6 | 12.60 | |
| GSK1059615 | MCF 10A | 10.0 | uM | 6 | hr | 225.75 | 115.01 | p-Akt | 12.62 | |
| Torkinib | AU565 | 2.37 | uM | 6 | hr | 226.24 | 41.45 | p-Akt | 12.62 | |
| MK2206 | T47D | 1.0 | nM | 6 | hr | 96.05 | 33.89 | p-Akt | 12.65 | |
| Torkinib | HCC1954 | 562.0 | nM | 6 | hr | 166.11 | 26.07 | p-Akt | 12.65 | |
| Dactolisib | AU565 | 316.0 | nM | 24 | hr | 436.33 | 59.46 | p-S6 | 12.66 | |
| GSK1059615 | MCF 10A | 10.0 | uM | 24 | hr | 197.93 | 71.11 | p-Akt | 12.70 | |
| Dactolisib | HCC1954 | 3.16 | uM | 6 | hr | 231.49 | 70.49 | p-S6 | 12.72 | |
| Dactolisib | HCC1954 | 1.0 | uM | 6 | hr | 235.94 | 70.90 | p-4EBP1 | 12.72 | |
| Torkinib | AU565 | 133.0 | nM | 6 | hr | 327.55 | 58.65 | p-S6 | 12.75 | |
| Torkinib | AU565 | 562.0 | nM | 24 | hr | 387.16 | 67.76 | p-4EBP1 | 12.75 | |
| Triciribine | T47D | 100.0 | nM | 6 | hr | 111.67 | 49.88 | p-Akt | 12.75 | |