Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Torkinib | MCF 10A | 2.37 | uM | 6 | hr | 620.84 | 155.04 | p-Akt | 19.11 | |
| Torkinib | MCF 10A | 0 (control) | 6 | hr | 502.64 | 155.63 | p-4EBP1 | 400.80 | | |
| Torkinib | MCF 10A | 0.1 | nM | 6 | hr | 454.27 | 168.14 | p-4EBP1 | 359.55 | |
| Torkinib | MCF 10A | 10.0 | uM | 6 | hr | 563.34 | 144.82 | p-Akt | 16.90 | |
| Torkinib | MCF 10A | 562.0 | nM | 6 | hr | 573.43 | 154.46 | p-Akt | 20.79 | |
| Torkinib | MCF 10A | 0 (control) | 6 | hr | 467.47 | 159.41 | p-4EBP1 | 396.36 | | |
| Torkinib | MCF 10A | 2.37 | uM | 6 | hr | 561.92 | 142.49 | p-Akt | 17.93 | |
| Torkinib | MCF 10A | 562.0 | nM | 6 | hr | 506.42 | 142.72 | p-Akt | 18.39 | |
| Torkinib | MCF 10A | 0.1 | nM | 6 | hr | 458.56 | 155.16 | p-Akt | 49.17 | |
| Torkinib | MCF 10A | 0.422 | nM | 6 | hr | 460.02 | 163.94 | p-4EBP1 | 355.88 | |
| Torkinib | MCF 10A | 562.0 | nM | 6 | hr | 615.73 | 171.90 | p-S6 | 618.02 | |
| Torkinib | MCF 10A | 2.37 | uM | 6 | hr | 630.91 | 159.45 | p-4EBP1 | 13.63 | |
| Torkinib | MCF 10A | 0.1 | nM | 6 | hr | 476.60 | 159.54 | p-S6 | 503.96 | |
| Torkinib | MCF 10A | 2.37 | uM | 6 | hr | 592.05 | 142.99 | p-S6 | 474.15 | |
| Torkinib | MCF 10A | 0.422 | nM | 6 | hr | 477.98 | 179.03 | p-S6 | 723.83 | |
| Torkinib | MCF 10A | 10.0 | uM | 6 | hr | 642.36 | 156.71 | p-4EBP1 | 7.99 | |
| Torkinib | MCF 10A | 133.0 | nM | 6 | hr | 466.79 | 144.13 | p-Akt | 22.20 | |
| Torkinib | MCF 10A | 7.5 | nM | 6 | hr | 476.93 | 164.79 | p-Akt | 37.69 | |
| Torkinib | MCF 10A | 31.6 | nM | 6 | hr | 500.56 | 171.56 | p-4EBP1 | 212.09 | |
| Torkinib | MCF 10A | 0.422 | nM | 6 | hr | 423.90 | 157.64 | p-Akt | 44.17 | |
| Torkinib | MCF 10A | 10.0 | uM | 6 | hr | 534.74 | 132.52 | p-Akt | 15.37 | |
| Torkinib | MCF 10A | 31.6 | nM | 6 | hr | 486.85 | 159.54 | p-4EBP1 | 207.18 | |
| Torkinib | MCF 10A | 10.0 | uM | 6 | hr | 575.82 | 163.71 | p-S6 | 376.86 | |
| Torkinib | MCF 10A | 133.0 | nM | 6 | hr | 498.92 | 152.17 | p-4EBP1 | 90.64 | |
| Torkinib | MCF 10A | 31.6 | nM | 6 | hr | 483.85 | 173.27 | p-S6 | 648.81 | |