Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Dactolisib | HCC1954 | 10.0 | uM | 6 | hr | 271.28 | 75.36 | p-S6 | 19.47 | |
| Dactolisib | HCC1954 | 0 (control) | 6 | hr | 255.38 | 84.53 | p-4EBP1 | 99.75 | | |
| Dactolisib | HCC1954 | 10.0 | nM | 6 | hr | 192.04 | 59.35 | p-Akt | 27.50 | |
| Dactolisib | HCC1954 | 10.0 | uM | 6 | hr | 280.52 | 78.67 | p-4EBP1 | 11.05 | |
| Dactolisib | HCC1954 | 316.0 | nM | 6 | hr | 193.59 | 49.84 | p-Akt | 12.54 | |
| Dactolisib | HCC1954 | 100.0 | nM | 6 | hr | 216.92 | 70.29 | p-4EBP1 | 13.19 | |
| Dactolisib | HCC1954 | 1.0 | nM | 6 | hr | 250.11 | 85.06 | p-4EBP1 | 113.97 | |
| Dactolisib | HCC1954 | 100.0 | nM | 6 | hr | 202.83 | 71.94 | p-S6 | 11.00 | |
| Dactolisib | HCC1954 | 10.0 | nM | 6 | hr | 162.93 | 43.47 | p-S6 | 11.98 | |
| Dactolisib | HCC1954 | 10.0 | uM | 6 | hr | 262.10 | 75.51 | p-Akt | 16.71 | |
| Dactolisib | HCC1954 | 1.0 | uM | 6 | hr | 207.47 | 62.19 | p-S6 | 11.17 | |
| Dactolisib | HCC1954 | 31.6 | nM | 6 | hr | 184.57 | 70.58 | p-4EBP1 | 27.57 | |
| Dactolisib | HCC1954 | 3.16 | nM | 6 | hr | 247.11 | 85.47 | p-4EBP1 | 110.31 | |
| Dactolisib | HCC1954 | 1.0 | nM | 6 | hr | 151.35 | 38.59 | p-Akt | 20.04 | |
| Dactolisib | HCC1954 | 316.0 | nM | 6 | hr | 195.79 | 64.22 | p-S6 | 10.13 | |
| Torkinib | HCC1954 | 0 (control) | 6 | hr | 182.67 | 40.88 | p-Akt | 23.74 | | |
| Torkinib | HCC1954 | 562.0 | nM | 6 | hr | 183.48 | 36.52 | p-4EBP1 | 10.85 | |
| Torkinib | HCC1954 | 562.0 | nM | 6 | hr | 146.89 | 24.95 | p-S6 | 10.19 | |
| Torkinib | HCC1954 | 0 (control) | 6 | hr | 182.11 | 41.43 | p-S6 | 89.40 | | |
| Torkinib | HCC1954 | 0.422 | nM | 6 | hr | 213.03 | 46.19 | p-Akt | 24.57 | |
| Torkinib | HCC1954 | 0.422 | nM | 6 | hr | 257.64 | 55.79 | p-Akt | 25.11 | |
| Torkinib | HCC1954 | 2.37 | uM | 6 | hr | 268.74 | 56.54 | p-Akt | 13.02 | |
| Torkinib | HCC1954 | 2.37 | uM | 6 | hr | 143.76 | 24.81 | p-S6 | 9.70 | |
| Torkinib | HCC1954 | 7.5 | nM | 6 | hr | 269.32 | 59.20 | p-S6 | 115.00 | |
| Torkinib | HCC1954 | 7.5 | nM | 6 | hr | 264.08 | 62.91 | p-4EBP1 | 67.81 | |