Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| GSK1059615 | AU565 | 316.0 | nM | 6 | hr | 274.58 | 58.70 | p-S6 | 34.90 | |
| GSK1059615 | AU565 | 0 (control) | 6 | hr | 234.34 | 56.31 | p-4EBP1 | 61.94 | | |
| GSK1059615 | AU565 | 3.16 | uM | 6 | hr | 226.42 | 50.58 | p-4EBP1 | 29.60 | |
| GSK1059615 | AU565 | 1.0 | uM | 6 | hr | 237.78 | 52.90 | p-S6 | 9.57 | |
| GSK1059615 | AU565 | 316.0 | nM | 6 | hr | 321.66 | 66.88 | p-4EBP1 | 90.79 | |
| GSK1059615 | AU565 | 3.16 | nM | 6 | hr | 279.66 | 70.10 | p-4EBP1 | 86.62 | |
| GSK1059615 | AU565 | 3.16 | nM | 6 | hr | 343.13 | 84.72 | p-Akt | 37.38 | |
| GSK1059615 | AU565 | 10.0 | nM | 6 | hr | 390.90 | 86.67 | p-S6 | 285.82 | |
| GSK1059615 | AU565 | 3.16 | uM | 6 | hr | 203.42 | 46.27 | p-S6 | 7.86 | |
| GSK1059615 | AU565 | 316.0 | nM | 6 | hr | 235.34 | 52.98 | p-S6 | 29.06 | |
| GSK1059615 | AU565 | 1.0 | uM | 6 | hr | 223.90 | 46.95 | p-S6 | 8.84 | |
| GSK1059615 | AU565 | 316.0 | nM | 6 | hr | 232.75 | 48.96 | p-Akt | 23.52 | |
| GSK1059615 | AU565 | 3.16 | nM | 6 | hr | 200.56 | 51.17 | p-S6 | 137.70 | |
| GSK1059615 | AU565 | 3.16 | uM | 6 | hr | 191.35 | 37.78 | p-Akt | 14.23 | |
| GSK1059615 | AU565 | 1.0 | nM | 6 | hr | 232.38 | 68.41 | p-S6 | 157.56 | |
| MK2206 | AU565 | 0 (control) | 6 | hr | 215.16 | 63.34 | p-Akt | 22.81 | | |
| MK2206 | AU565 | 10.0 | nM | 6 | hr | 183.97 | 46.00 | p-Akt | 14.47 | |
| MK2206 | AU565 | 1.0 | nM | 6 | hr | 380.99 | 91.20 | p-S6 | 338.00 | |
| MK2206 | AU565 | 316.0 | nM | 6 | hr | 266.67 | 61.68 | p-Akt | 13.97 | |
| MK2206 | AU565 | 31.6 | nM | 6 | hr | 316.88 | 74.06 | p-S6 | 151.34 | |
| MK2206 | AU565 | 3.16 | nM | 6 | hr | 292.99 | 75.06 | p-Akt | 24.55 | |
| MK2206 | AU565 | 3.16 | uM | 6 | hr | 256.25 | 58.14 | p-Akt | 13.28 | |
| MK2206 | AU565 | 316.0 | nM | 6 | hr | 365.11 | 76.85 | p-S6 | 156.15 | |
| MK2206 | AU565 | 10.0 | uM | 6 | hr | 310.26 | 62.42 | p-Akt | 15.88 | |
| MK2206 | AU565 | 3.16 | nM | 6 | hr | 207.40 | 54.85 | p-4EBP1 | 68.29 | |