HMS LINCS Project

Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)

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Small molecules	Cells
10057:MK2206 10098:Gefitinib 10172:GSK1059615 10232:Dactolisib 10280:Triciribine 10345:Torkinib	50091:AU565 50213:HCC1954 50541:T47D 50583:MCF 10A

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Small Molecule	Cell Line	Drug Concentration	Conc Units	Timepoint	Timepoint Units	Measured pERK (Alexa 488)	Measured p-Rb (Alexa 568)	Alexa Fluor 647	Measured p-Akt/p-4EBP1/p-S6 (Alexa 647)	Image
Torkinib	HCC1954	0.422	nM	6	hr	257.64	55.79	p-Akt	25.11
Torkinib	MCF 10A	0.422	nM	6	hr	475.26	169.60	p-Akt	43.49
Torkinib	T47D	0.422	nM	24	hr	165.87	94.49	p-Akt	59.39
Torkinib	AU565	0.422	nM	6	hr	323.79	66.32	p-Akt	30.57
Torkinib	T47D	0.422	nM	24	hr	171.91	116.89	p-S6	335.63
Torkinib	AU565	0.422	nM	24	hr	486.69	109.36	p-Akt	78.15
Torkinib	MCF 10A	0.422	nM	24	hr	365.79	140.07	p-Akt	43.54
Torkinib	T47D	0.422	nM	6	hr	176.07	86.72	p-Akt	75.19
Torkinib	AU565	0.422	nM	6	hr	372.97	73.36	p-4EBP1	96.01
Torkinib	HCC1954	0.422	nM	6	hr	204.28	49.24	p-S6	118.41
Torkinib	AU565	0.422	nM	24	hr	486.10	119.56	p-S6	478.18
Torkinib	HCC1954	0.422	nM	24	hr	288.79	112.90	p-S6	376.36
Torkinib	AU565	0.422	nM	6	hr	297.99	64.59	p-S6	137.32
Torkinib	MCF 10A	0.422	nM	6	hr	430.95	160.56	p-S6	549.49
Torkinib	T47D	0.422	nM	24	hr	164.15	114.64	p-4EBP1	409.39
Torkinib	MCF 10A	0.422	nM	24	hr	401.13	169.08	p-S6	399.89
Torkinib	HCC1954	0.422	nM	24	hr	272.73	120.17	p-4EBP1	122.70
Torkinib	HCC1954	0.422	nM	6	hr	168.42	32.42	p-4EBP1	42.36
Torkinib	MCF 10A	0.422	nM	6	hr	460.02	163.94	p-4EBP1	355.88
Torkinib	HCC1954	0.422	nM	6	hr	213.03	46.19	p-Akt	24.57
Torkinib	AU565	0.422	nM	6	hr	325.27	66.60	p-4EBP1	88.50
Torkinib	MCF 10A	0.422	nM	6	hr	423.90	157.64	p-Akt	44.17
Torkinib	HCC1954	0.422	nM	24	hr	275.88	108.45	p-Akt	62.94
Torkinib	AU565	0.422	nM	24	hr	462.08	119.67	p-4EBP1	200.90
Torkinib	MCF 10A	0.422	nM	24	hr	321.05	157.86	p-4EBP1	262.23

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