HMS LINCS Project

Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)

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Small molecules	Cells
10057:MK2206 10098:Gefitinib 10172:GSK1059615 10232:Dactolisib 10280:Triciribine 10345:Torkinib	50091:AU565 50213:HCC1954 50541:T47D 50583:MCF 10A

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Small Molecule	Cell Line	Drug Concentration	Conc Units	Timepoint	Timepoint Units	Measured pERK (Alexa 488)	Measured p-Rb (Alexa 568)	Alexa Fluor 647	Measured p-Akt/p-4EBP1/p-S6 (Alexa 647)	Image
Torkinib	MCF 10A	0.1	nM	24	hr	422.39	160.17	p-S6	363.48
Torkinib	HCC1954	0.1	nM	6	hr	184.48	44.56	p-S6	110.17
Torkinib	HCC1954	0.1	nM	24	hr	274.70	113.00	p-S6	380.78
Torkinib	HCC1954	0.1	nM	24	hr	291.18	108.05	p-S6	406.86
Torkinib	MCF 10A	0.1	nM	6	hr	500.23	174.95	p-S6	699.38
Torkinib	AU565	0.1	nM	24	hr	484.31	116.72	p-Akt	84.98
Torkinib	HCC1954	0.1	nM	6	hr	195.86	37.51	p-Akt	23.03
Torkinib	MCF 10A	0.1	nM	6	hr	458.56	155.16	p-Akt	49.17
Torkinib	MCF 10A	0.1	nM	24	hr	342.29	124.00	p-Akt	50.29
Torkinib	AU565	0.1	nM	6	hr	249.91	55.55	p-Akt	24.44
Torkinib	AU565	0.1	nM	24	hr	513.30	118.22	p-Akt	83.59
Torkinib	HCC1954	0.1	nM	24	hr	300.36	112.32	p-Akt	67.70
Torkinib	MCF 10A	0.1	nM	6	hr	483.02	168.09	p-Akt	48.88
Torkinib	AU565	0.1	nM	6	hr	346.86	73.14	p-4EBP1	98.91
Torkinib	AU565	0.1	nM	24	hr	484.96	127.02	p-4EBP1	215.15
Torkinib	HCC1954	0.1	nM	24	hr	268.67	120.63	p-4EBP1	124.48
Torkinib	MCF 10A	0.1	nM	6	hr	452.64	159.11	p-4EBP1	351.84
Torkinib	T47D	0.1	nM	24	hr	157.07	112.77	p-4EBP1	421.70
Torkinib	AU565	0.1	nM	6	hr	226.90	50.34	p-4EBP1	59.83
Torkinib	HCC1954	0.1	nM	6	hr	179.96	38.18	p-4EBP1	49.70
Torkinib	HCC1954	0.1	nM	24	hr	294.96	117.90	p-4EBP1	132.58
Torkinib	AU565	0.1	nM	6	hr	230.65	52.24	p-Akt	23.88
Torkinib	AU565	0.1	nM	6	hr	259.18	62.54	p-S6	155.57
Torkinib	MCF 10A	0.422	nM	6	hr	430.95	160.56	p-S6	549.49
Torkinib	HCC1954	0.422	nM	24	hr	288.79	112.90	p-S6	376.36

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