Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Triciribine | MCF 10A | 0 (control) | 24 | hr | 333.49 | 112.55 | p-Akt | 47.91 | | |
| GSK1059615 | T47D | 0 (control) | 6 | hr | 170.99 | 85.49 | p-4EBP1 | 487.39 | | |
| MK2206 | HCC1954 | 0 (control) | 6 | hr | 248.38 | 75.69 | p-S6 | 177.47 | | |
| Dactolisib | MCF 10A | 0 (control) | 6 | hr | 436.72 | 165.98 | p-Akt | 55.27 | | |
| Triciribine | T47D | 0 (control) | 6 | hr | 91.82 | 35.81 | p-4EBP1 | 108.61 | | |
| Dactolisib | HCC1954 | 0 (control) | 24 | hr | 328.01 | 114.08 | p-S6 | 351.21 | | |
| MK2206 | T47D | 0 (control) | 24 | hr | 168.35 | 111.49 | p-4EBP1 | 409.81 | | |
| Torkinib | MCF 10A | 0 (control) | 6 | hr | 487.61 | 155.47 | p-S6 | 474.69 | | |
| Triciribine | T47D | 0 (control) | 24 | hr | 156.16 | 103.29 | p-4EBP1 | 393.33 | | |
| Dactolisib | T47D | 0 (control) | 24 | hr | 136.31 | 100.86 | p-4EBP1 | 345.05 | | |
| Dactolisib | T47D | 0 (control) | 6 | hr | 102.03 | 45.53 | p-4EBP1 | 121.29 | | |
| MK2206 | T47D | 0 (control) | 6 | hr | 108.26 | 31.89 | p-4EBP1 | 66.68 | | |
| MK2206 | AU565 | 0 (control) | 6 | hr | 273.26 | 74.15 | p-4EBP1 | 88.08 | | |
| Triciribine | AU565 | 0 (control) | 6 | hr | 231.71 | 61.01 | p-Akt | 21.54 | | |
| Torkinib | T47D | 0 (control) | 6 | hr | 178.21 | 89.61 | p-4EBP1 | 518.71 | | |
| GSK1059615 | HCC1954 | 0 (control) | 24 | hr | 302.50 | 106.62 | p-Akt | 73.55 | | |
| GSK1059615 | AU565 | 0 (control) | 24 | hr | 447.87 | 123.71 | p-4EBP1 | 188.29 | | |
| Dactolisib | HCC1954 | 0 (control) | 6 | hr | 182.86 | 43.74 | p-4EBP1 | 53.60 | | |
| Gefitinib | T47D | 0 (control) | 6 | hr | 203.12 | 105.90 | p-S6 | 455.20 | | |
| Gefitinib | T47D | 0 (control) | 6 | hr | 176.65 | 97.90 | p-Akt | 103.18 | | |
| MK2206 | HCC1954 | 0 (control) | 24 | hr | 298.17 | 123.52 | p-4EBP1 | 156.31 | | |
| Triciribine | HCC1954 | 0 (control) | 6 | hr | 217.78 | 65.35 | p-4EBP1 | 91.17 | | |
| GSK1059615 | HCC1954 | 0 (control) | 6 | hr | 337.11 | 90.46 | p-4EBP1 | 107.99 | | |
| GSK1059615 | HCC1954 | 0 (control) | 24 | hr | 360.97 | 111.76 | p-S6 | 338.33 | | |
| Triciribine | HCC1954 | 0 (control) | 24 | hr | 333.42 | 105.27 | p-S6 | 310.92 | |