Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
Download: Excel (XLSX), Comma-separated (CSV)
| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Torkinib | HCC1954 | 7.5 | nM | 6 | hr | 189.93 | 35.55 | p-Akt | 16.14 | |
| Torkinib | AU565 | 7.5 | nM | 6 | hr | 240.99 | 44.76 | p-Akt | 15.24 | |
| Torkinib | HCC1954 | 7.5 | nM | 6 | hr | 269.32 | 59.20 | p-S6 | 115.00 | |
| Torkinib | HCC1954 | 7.5 | nM | 24 | hr | 261.97 | 105.02 | p-S6 | 381.35 | |
| Torkinib | AU565 | 7.5 | nM | 24 | hr | 441.84 | 88.60 | p-Akt | 51.74 | |
| Torkinib | HCC1954 | 7.5 | nM | 6 | hr | 176.66 | 32.26 | p-4EBP1 | 41.13 | |
| Torkinib | MCF 10A | 7.5 | nM | 6 | hr | 516.67 | 184.66 | p-S6 | 775.89 | |
| Torkinib | MCF 10A | 7.5 | nM | 24 | hr | 488.46 | 184.47 | p-S6 | 594.52 | |
| Torkinib | T47D | 7.5 | nM | 24 | hr | 139.90 | 103.43 | p-S6 | 294.61 | |
| Torkinib | T47D | 7.5 | nM | 6 | hr | 171.51 | 80.43 | p-Akt | 46.98 | |
| Torkinib | T47D | 7.5 | nM | 6 | hr | 166.58 | 112.68 | p-S6 | 419.40 | |
| Torkinib | T47D | 7.5 | nM | 24 | hr | 146.08 | 97.87 | p-S6 | 269.37 | |
| Torkinib | HCC1954 | 7.5 | nM | 24 | hr | 252.28 | 107.51 | p-4EBP1 | 112.23 | |
| Torkinib | AU565 | 7.5 | nM | 6 | hr | 383.95 | 66.61 | p-S6 | 58.91 | |
| Torkinib | T47D | 7.5 | nM | 24 | hr | 134.56 | 75.54 | p-4EBP1 | 293.71 | |
| Torkinib | T47D | 7.5 | nM | 6 | hr | 164.77 | 78.46 | p-4EBP1 | 425.95 | |
| Torkinib | MCF 10A | 7.5 | nM | 24 | hr | 392.70 | 173.87 | p-4EBP1 | 178.68 | |
| Torkinib | MCF 10A | 7.5 | nM | 6 | hr | 454.63 | 172.76 | p-4EBP1 | 304.51 | |
| Torkinib | HCC1954 | 7.5 | nM | 24 | hr | 266.85 | 111.10 | p-4EBP1 | 127.79 | |
| Torkinib | HCC1954 | 7.5 | nM | 6 | hr | 264.08 | 62.91 | p-4EBP1 | 67.81 | |
| Torkinib | AU565 | 7.5 | nM | 24 | hr | 429.01 | 96.59 | p-4EBP1 | 145.95 | |
| Torkinib | AU565 | 7.5 | nM | 6 | hr | 277.07 | 52.38 | p-4EBP1 | 54.13 | |
| Torkinib | AU565 | 7.5 | nM | 24 | hr | 415.91 | 89.31 | p-S6 | 194.93 | |
| Torkinib | AU565 | 7.5 | nM | 6 | hr | 237.10 | 47.79 | p-4EBP1 | 50.80 | |
| Torkinib | T47D | 7.5 | nM | 6 | hr | 162.62 | 84.08 | p-4EBP1 | 434.94 | |