Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
Download: Excel (XLSX), Comma-separated (CSV)
| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Gefitinib | T47D | 0 (control) | 24 | hr | 177.88 | 116.19 | p-Akt | 85.23 | | |
| Gefitinib | HCC1954 | 0 (control) | 24 | hr | 342.49 | 120.54 | p-Akt | 84.26 | | |
| MK2206 | AU565 | 0 (control) | 6 | hr | 273.26 | 74.15 | p-4EBP1 | 88.08 | | |
| MK2206 | AU565 | 0 (control) | 24 | hr | 443.02 | 135.36 | p-4EBP1 | 212.85 | | |
| GSK1059615 | AU565 | 0 (control) | 24 | hr | 447.87 | 123.71 | p-4EBP1 | 188.29 | | |
| GSK1059615 | MCF 10A | 0 (control) | 6 | hr | 450.57 | 164.32 | p-Akt | 55.84 | | |
| MK2206 | MCF 10A | 0 (control) | 24 | hr | 315.18 | 126.11 | p-Akt | 50.02 | | |
| Torkinib | MCF 10A | 0 (control) | 24 | hr | 321.43 | 144.06 | p-4EBP1 | 397.50 | | |
| Triciribine | MCF 10A | 0 (control) | 24 | hr | 301.15 | 117.66 | p-Akt | 45.04 | | |
| Gefitinib | T47D | 0 (control) | 6 | hr | 187.71 | 94.01 | p-Akt | 103.59 | | |
| Gefitinib | T47D | 0 (control) | 24 | hr | 170.59 | 100.50 | p-Akt | 77.77 | | |
| Torkinib | T47D | 0 (control) | 24 | hr | 159.62 | 95.25 | p-Akt | 70.79 | | |
| GSK1059615 | T47D | 0 (control) | 6 | hr | 156.94 | 85.75 | p-Akt | 89.93 | | |
| MK2206 | HCC1954 | 0 (control) | 6 | hr | 271.78 | 84.99 | p-Akt | 42.06 | | |
| Dactolisib | HCC1954 | 0 (control) | 6 | hr | 182.86 | 43.74 | p-4EBP1 | 53.60 | | |
| Gefitinib | HCC1954 | 0 (control) | 24 | hr | 288.02 | 127.19 | p-4EBP1 | 143.69 | | |
| Triciribine | T47D | 0 (control) | 24 | hr | 176.48 | 88.36 | p-Akt | 66.59 | | |
| Triciribine | HCC1954 | 0 (control) | 6 | hr | 257.62 | 89.88 | p-S6 | 373.72 | | |
| Triciribine | AU565 | 0 (control) | 24 | hr | 518.22 | 130.83 | p-4EBP1 | 239.81 | | |
| Dactolisib | HCC1954 | 0 (control) | 24 | hr | 328.01 | 114.08 | p-S6 | 351.21 | | |
| Dactolisib | AU565 | 0 (control) | 6 | hr | 223.15 | 50.37 | p-4EBP1 | 55.92 | | |
| MK2206 | HCC1954 | 0 (control) | 6 | hr | 142.39 | 29.98 | p-4EBP1 | 49.89 | | |
| MK2206 | HCC1954 | 0 (control) | 24 | hr | 298.17 | 123.52 | p-4EBP1 | 156.31 | | |
| Triciribine | HCC1954 | 0 (control) | 6 | hr | 217.78 | 65.35 | p-4EBP1 | 91.17 | | |
| Gefitinib | T47D | 0 (control) | 6 | hr | 176.65 | 97.90 | p-Akt | 103.18 | |