HMS LINCS Project

Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)

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Small molecules	Cells
10057:MK2206 10098:Gefitinib 10172:GSK1059615 10232:Dactolisib 10280:Triciribine 10345:Torkinib	50091:AU565 50213:HCC1954 50541:T47D 50583:MCF 10A

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Small Molecule	Cell Line	Drug Concentration	Conc Units	Timepoint	Timepoint Units	Measured pERK (Alexa 488)	Measured p-Rb (Alexa 568)	Alexa Fluor 647	Measured p-Akt/p-4EBP1/p-S6 (Alexa 647)	Image
Dactolisib	AU565	100.0	nM	6	hr	290.65	59.15	p-Akt	17.08
GSK1059615	MCF 10A	3.16	nM	6	hr	413.32	170.40	p-4EBP1	360.27
Dactolisib	AU565	100.0	nM	24	hr	377.63	60.16	p-Akt	25.52
GSK1059615	MCF 10A	3.16	nM	24	hr	367.96	143.08	p-Akt	41.13
Gefitinib	HCC1954	100.0	nM	6	hr	166.09	41.51	p-Akt	23.50
Triciribine	MCF 10A	3.16	nM	6	hr	393.04	157.90	p-4EBP1	362.41
Gefitinib	HCC1954	100.0	nM	24	hr	271.49	112.65	p-Akt	74.36
MK2206	MCF 10A	3.16	nM	6	hr	401.94	154.74	p-Akt	43.87
Torkinib	HCC1954	31.6	nM	6	hr	150.07	28.76	p-Akt	14.38
Gefitinib	T47D	3.16	nM	6	hr	186.66	102.68	p-4EBP1	497.08
Torkinib	HCC1954	31.6	nM	24	hr	250.65	86.99	p-Akt	39.42
MK2206	MCF 10A	3.16	nM	24	hr	313.82	137.95	p-Akt	41.12
GSK1059615	HCC1954	100.0	nM	6	hr	324.83	87.89	p-Akt	34.01
Gefitinib	AU565	1.0	nM	6	hr	289.01	63.74	p-4EBP1	68.42
GSK1059615	HCC1954	100.0	nM	24	hr	285.12	84.64	p-Akt	37.56
Triciribine	MCF 10A	3.16	nM	6	hr	404.45	155.90	p-Akt	44.15
MK2206	HCC1954	100.0	nM	6	hr	239.59	77.83	p-Akt	17.44
GSK1059615	AU565	1.0	nM	6	hr	261.27	65.61	p-4EBP1	75.05
MK2206	HCC1954	100.0	nM	24	hr	248.97	102.29	p-Akt	31.95
Triciribine	MCF 10A	3.16	nM	24	hr	272.12	127.39	p-Akt	34.72
Triciribine	HCC1954	100.0	nM	6	hr	200.10	73.80	p-Akt	29.38
Triciribine	AU565	1.0	nM	6	hr	291.94	77.13	p-4EBP1	98.69
Triciribine	HCC1954	100.0	nM	24	hr	238.17	94.17	p-Akt	36.41
Dactolisib	MCF 10A	3.16	nM	6	hr	394.32	173.00	p-Akt	43.59
Gefitinib	T47D	100.0	nM	6	hr	160.51	99.08	p-4EBP1	483.73

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