Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Torkinib | T47D | 0 (control) | 6 | hr | 175.86 | 85.25 | p-Akt | 102.65 | | |
| Gefitinib | T47D | 0 (control) | 24 | hr | 170.59 | 100.50 | p-Akt | 77.77 | | |
| Gefitinib | T47D | 0 (control) | 6 | hr | 187.71 | 94.01 | p-Akt | 103.59 | | |
| Dactolisib | MCF 10A | 0 (control) | 24 | hr | 343.08 | 120.76 | p-Akt | 47.16 | | |
| Dactolisib | MCF 10A | 0 (control) | 6 | hr | 422.77 | 156.53 | p-Akt | 48.09 | | |
| Triciribine | MCF 10A | 0 (control) | 24 | hr | 301.15 | 117.66 | p-Akt | 45.04 | | |
| Triciribine | MCF 10A | 0 (control) | 6 | hr | 445.27 | 158.74 | p-Akt | 51.39 | | |
| MK2206 | MCF 10A | 0 (control) | 24 | hr | 315.18 | 126.11 | p-Akt | 50.02 | | |
| MK2206 | MCF 10A | 0 (control) | 6 | hr | 444.42 | 158.52 | p-Akt | 51.11 | | |
| GSK1059615 | MCF 10A | 0 (control) | 24 | hr | 310.41 | 122.11 | p-Akt | 47.38 | | |
| GSK1059615 | MCF 10A | 0 (control) | 6 | hr | 463.38 | 170.08 | p-Akt | 54.25 | | |
| Torkinib | MCF 10A | 0 (control) | 24 | hr | 322.85 | 121.43 | p-Akt | 50.42 | | |
| Torkinib | MCF 10A | 0 (control) | 6 | hr | 536.28 | 163.68 | p-Akt | 59.35 | | |
| Gefitinib | MCF 10A | 0 (control) | 24 | hr | 287.60 | 121.02 | p-Akt | 55.55 | | |
| Gefitinib | MCF 10A | 0 (control) | 6 | hr | 469.08 | 161.04 | p-Akt | 50.22 | | |
| Dactolisib | HCC1954 | 0 (control) | 24 | hr | 307.41 | 110.59 | p-Akt | 70.74 | | |
| Dactolisib | HCC1954 | 0 (control) | 6 | hr | 264.91 | 93.02 | p-Akt | 54.82 | | |
| Triciribine | HCC1954 | 0 (control) | 24 | hr | 327.74 | 105.87 | p-Akt | 62.61 | | |
| Triciribine | HCC1954 | 0 (control) | 6 | hr | 321.42 | 95.62 | p-Akt | 60.23 | | |
| MK2206 | HCC1954 | 0 (control) | 24 | hr | 320.12 | 114.08 | p-Akt | 71.27 | | |
| MK2206 | HCC1954 | 0 (control) | 6 | hr | 288.90 | 82.72 | p-Akt | 40.72 | | |
| GSK1059615 | HCC1954 | 0 (control) | 24 | hr | 497.27 | 121.23 | p-Akt | 77.13 | | |
| GSK1059615 | HCC1954 | 0 (control) | 6 | hr | 556.41 | 101.00 | p-Akt | 80.71 | | |
| Torkinib | HCC1954 | 0 (control) | 24 | hr | 290.34 | 108.98 | p-Akt | 69.98 | | |
| Torkinib | HCC1954 | 0 (control) | 6 | hr | 192.87 | 39.64 | p-Akt | 23.38 | |