Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Gefitinib | AU565 | 0 (control) | 6 | hr | 234.75 | 54.33 | p-Akt | 24.82 | | |
| Dactolisib | T47D | 0 (control) | 24 | hr | 150.93 | 113.70 | p-S6 | 316.63 | | |
| Dactolisib | T47D | 0 (control) | 6 | hr | 102.85 | 43.35 | p-S6 | 72.78 | | |
| Triciribine | T47D | 0 (control) | 24 | hr | 178.57 | 98.11 | p-S6 | 353.20 | | |
| Triciribine | T47D | 0 (control) | 6 | hr | 93.67 | 36.69 | p-S6 | 48.97 | | |
| MK2206 | T47D | 0 (control) | 24 | hr | 171.54 | 104.31 | p-S6 | 349.95 | | |
| MK2206 | T47D | 0 (control) | 6 | hr | 93.24 | 32.03 | p-S6 | 42.80 | | |
| GSK1059615 | T47D | 0 (control) | 24 | hr | 166.64 | 96.53 | p-S6 | 333.24 | | |
| GSK1059615 | T47D | 0 (control) | 6 | hr | 170.67 | 95.63 | p-S6 | 471.82 | | |
| Torkinib | T47D | 0 (control) | 24 | hr | 163.35 | 103.26 | p-S6 | 318.44 | | |
| Torkinib | T47D | 0 (control) | 6 | hr | 189.83 | 98.37 | p-S6 | 444.84 | | |
| Gefitinib | T47D | 0 (control) | 24 | hr | 170.23 | 118.41 | p-S6 | 337.47 | | |
| Gefitinib | T47D | 0 (control) | 6 | hr | 203.12 | 105.90 | p-S6 | 455.20 | | |
| Dactolisib | MCF 10A | 0 (control) | 24 | hr | 279.32 | 117.75 | p-S6 | 230.59 | | |
| Dactolisib | MCF 10A | 0 (control) | 6 | hr | 464.95 | 166.23 | p-S6 | 565.63 | | |
| Triciribine | MCF 10A | 0 (control) | 24 | hr | 284.26 | 123.08 | p-S6 | 227.29 | | |
| Triciribine | MCF 10A | 0 (control) | 6 | hr | 446.41 | 161.85 | p-S6 | 482.53 | | |
| MK2206 | MCF 10A | 0 (control) | 24 | hr | 356.25 | 145.59 | p-S6 | 253.80 | | |
| MK2206 | MCF 10A | 0 (control) | 6 | hr | 444.39 | 161.44 | p-S6 | 482.27 | | |
| GSK1059615 | MCF 10A | 0 (control) | 24 | hr | 366.02 | 152.69 | p-S6 | 363.09 | | |
| GSK1059615 | MCF 10A | 0 (control) | 6 | hr | 462.01 | 162.67 | p-S6 | 489.57 | | |
| Torkinib | MCF 10A | 0 (control) | 24 | hr | 411.50 | 147.39 | p-S6 | 316.45 | | |
| Torkinib | MCF 10A | 0 (control) | 6 | hr | 487.61 | 155.47 | p-S6 | 474.69 | | |
| Gefitinib | MCF 10A | 0 (control) | 24 | hr | 338.27 | 145.29 | p-S6 | 360.92 | | |
| Gefitinib | MCF 10A | 0 (control) | 6 | hr | 472.26 | 160.00 | p-S6 | 457.50 | |