Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| GSK1059615 | T47D | 0 (control) | 24 | hr | 157.54 | 89.78 | p-Akt | 65.53 | | |
| GSK1059615 | T47D | 0 (control) | 6 | hr | 156.94 | 85.75 | p-Akt | 89.93 | | |
| Torkinib | T47D | 0 (control) | 24 | hr | 159.62 | 95.25 | p-Akt | 70.79 | | |
| Torkinib | T47D | 0 (control) | 6 | hr | 175.86 | 85.25 | p-Akt | 102.65 | | |
| Gefitinib | T47D | 0 (control) | 24 | hr | 170.59 | 100.50 | p-Akt | 77.77 | | |
| Gefitinib | T47D | 0 (control) | 6 | hr | 187.71 | 94.01 | p-Akt | 103.59 | | |
| Dactolisib | T47D | 1.0 | uM | 24 | hr | 115.16 | 30.63 | p-Akt | 12.53 | |
| Dactolisib | T47D | 1.0 | uM | 6 | hr | 90.30 | 37.28 | p-Akt | 6.14 | |
| Triciribine | T47D | 1.0 | uM | 24 | hr | 168.38 | 70.15 | p-Akt | 36.06 | |
| Triciribine | T47D | 1.0 | uM | 6 | hr | 119.47 | 61.20 | p-Akt | 13.24 | |
| MK2206 | T47D | 1.0 | uM | 24 | hr | 138.60 | 47.77 | p-Akt | 13.85 | |
| MK2206 | T47D | 1.0 | uM | 6 | hr | 107.58 | 49.92 | p-Akt | 7.19 | |
| GSK1059615 | T47D | 1.0 | uM | 24 | hr | 151.68 | 44.97 | p-Akt | 17.97 | |
| GSK1059615 | T47D | 1.0 | uM | 6 | hr | 158.41 | 63.89 | p-Akt | 21.30 | |
| Torkinib | T47D | 562.0 | nM | 24 | hr | 119.35 | 36.17 | p-Akt | 13.61 | |
| Torkinib | T47D | 562.0 | nM | 6 | hr | 149.87 | 76.09 | p-Akt | 15.96 | |
| Gefitinib | T47D | 1.0 | uM | 24 | hr | 156.94 | 108.01 | p-Akt | 80.72 | |
| Gefitinib | T47D | 1.0 | uM | 6 | hr | 160.75 | 102.16 | p-Akt | 104.17 | |
| Gefitinib | T47D | 31.6 | nM | 6 | hr | 171.24 | 91.49 | p-4EBP1 | 465.53 | |
| Gefitinib | T47D | 31.6 | nM | 24 | hr | 153.72 | 115.23 | p-4EBP1 | 404.00 | |
| Torkinib | T47D | 7.5 | nM | 6 | hr | 164.77 | 78.46 | p-4EBP1 | 425.95 | |
| Torkinib | T47D | 7.5 | nM | 24 | hr | 134.56 | 75.54 | p-4EBP1 | 293.71 | |
| GSK1059615 | T47D | 31.6 | nM | 6 | hr | 175.93 | 85.52 | p-4EBP1 | 483.66 | |
| GSK1059615 | T47D | 31.6 | nM | 24 | hr | 144.33 | 101.31 | p-4EBP1 | 406.55 | |
| MK2206 | T47D | 31.6 | nM | 6 | hr | 99.94 | 45.83 | p-4EBP1 | 109.15 | |