Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| GSK1059615 | T47D | 10.0 | nM | 24 | hr | 145.52 | 103.20 | p-4EBP1 | 390.37 | |
| MK2206 | T47D | 10.0 | nM | 6 | hr | 91.29 | 31.15 | p-4EBP1 | 65.25 | |
| MK2206 | T47D | 10.0 | nM | 24 | hr | 136.84 | 105.94 | p-4EBP1 | 360.37 | |
| Triciribine | T47D | 10.0 | nM | 6 | hr | 99.74 | 56.25 | p-4EBP1 | 160.51 | |
| Triciribine | T47D | 10.0 | nM | 24 | hr | 155.46 | 103.90 | p-4EBP1 | 352.38 | |
| Dactolisib | T47D | 10.0 | nM | 6 | hr | 89.53 | 39.74 | p-4EBP1 | 114.99 | |
| Dactolisib | T47D | 10.0 | nM | 24 | hr | 140.73 | 91.20 | p-4EBP1 | 304.17 | |
| Dactolisib | T47D | 1.0 | nM | 24 | hr | 151.06 | 89.06 | p-Akt | 44.96 | |
| Dactolisib | T47D | 1.0 | nM | 6 | hr | 92.92 | 41.52 | p-Akt | 14.33 | |
| Triciribine | T47D | 1.0 | nM | 24 | hr | 163.02 | 95.08 | p-Akt | 67.15 | |
| Triciribine | T47D | 1.0 | nM | 6 | hr | 102.04 | 43.09 | p-Akt | 16.40 | |
| MK2206 | T47D | 1.0 | nM | 24 | hr | 178.24 | 100.47 | p-Akt | 57.48 | |
| MK2206 | T47D | 1.0 | nM | 6 | hr | 96.05 | 33.89 | p-Akt | 12.65 | |
| GSK1059615 | T47D | 1.0 | nM | 24 | hr | 156.20 | 90.59 | p-Akt | 63.43 | |
| GSK1059615 | T47D | 1.0 | nM | 6 | hr | 163.85 | 87.64 | p-Akt | 92.36 | |
| Torkinib | T47D | 0.1 | nM | 24 | hr | 170.63 | 99.96 | p-Akt | 65.73 | |
| Torkinib | T47D | 0.1 | nM | 6 | hr | 177.18 | 86.32 | p-Akt | 86.42 | |
| Gefitinib | T47D | 1.0 | nM | 24 | hr | 169.83 | 103.51 | p-Akt | 76.42 | |
| Gefitinib | T47D | 1.0 | nM | 6 | hr | 186.25 | 95.12 | p-Akt | 100.55 | |
| Dactolisib | T47D | 0 (control) | 24 | hr | 164.85 | 91.26 | p-Akt | 58.26 | | |
| Dactolisib | T47D | 0 (control) | 6 | hr | 93.59 | 40.79 | p-Akt | 16.04 | | |
| Triciribine | T47D | 0 (control) | 24 | hr | 176.48 | 88.36 | p-Akt | 66.59 | | |
| Triciribine | T47D | 0 (control) | 6 | hr | 98.11 | 30.56 | p-Akt | 14.84 | | |
| MK2206 | T47D | 0 (control) | 24 | hr | 168.73 | 94.72 | p-Akt | 64.26 | | |
| MK2206 | T47D | 0 (control) | 6 | hr | 93.47 | 32.94 | p-Akt | 14.46 | |