Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Triciribine | T47D | 10.0 | uM | 24 | hr | 170.17 | 66.91 | p-S6 | 405.92 | |
| Dactolisib | T47D | 10.0 | uM | 6 | hr | 88.85 | 36.94 | p-S6 | 4.07 | |
| Dactolisib | T47D | 10.0 | uM | 24 | hr | 137.63 | 102.12 | p-S6 | 6.93 | |
| Gefitinib | T47D | 31.6 | nM | 6 | hr | 169.24 | 103.77 | p-S6 | 460.35 | |
| Gefitinib | T47D | 31.6 | nM | 24 | hr | 149.77 | 109.46 | p-S6 | 333.14 | |
| Torkinib | T47D | 7.5 | nM | 6 | hr | 166.58 | 112.68 | p-S6 | 419.40 | |
| Torkinib | T47D | 7.5 | nM | 24 | hr | 146.08 | 97.87 | p-S6 | 269.37 | |
| GSK1059615 | T47D | 31.6 | nM | 6 | hr | 160.95 | 94.61 | p-S6 | 469.60 | |
| GSK1059615 | T47D | 31.6 | nM | 24 | hr | 141.25 | 93.47 | p-S6 | 327.24 | |
| MK2206 | T47D | 31.6 | nM | 6 | hr | 91.91 | 38.77 | p-S6 | 39.68 | |
| MK2206 | T47D | 31.6 | nM | 24 | hr | 140.64 | 98.09 | p-S6 | 373.71 | |
| Triciribine | T47D | 31.6 | nM | 6 | hr | 106.22 | 57.85 | p-S6 | 76.25 | |
| Triciribine | T47D | 31.6 | nM | 24 | hr | 157.98 | 94.11 | p-S6 | 386.15 | |
| Dactolisib | T47D | 31.6 | nM | 6 | hr | 97.27 | 52.91 | p-S6 | 5.12 | |
| Dactolisib | T47D | 31.6 | nM | 24 | hr | 159.25 | 59.11 | p-S6 | 13.01 | |
| Dactolisib | T47D | 10.0 | uM | 24 | hr | 153.18 | 108.52 | p-Akt | 16.83 | |
| Dactolisib | T47D | 10.0 | uM | 6 | hr | 93.15 | 46.29 | p-Akt | 6.63 | |
| Triciribine | T47D | 10.0 | uM | 24 | hr | 179.90 | 57.17 | p-Akt | 33.20 | |
| Triciribine | T47D | 10.0 | uM | 6 | hr | 110.90 | 45.64 | p-Akt | 9.31 | |
| MK2206 | T47D | 10.0 | uM | 24 | hr | 188.01 | 51.80 | p-Akt | 14.95 | |
| MK2206 | T47D | 10.0 | uM | 6 | hr | 110.32 | 28.55 | p-Akt | 6.57 | |
| GSK1059615 | T47D | 10.0 | uM | 24 | hr | 190.43 | 66.91 | p-Akt | 17.57 | |
| GSK1059615 | T47D | 10.0 | uM | 6 | hr | 189.09 | 66.04 | p-Akt | 16.13 | |
| Torkinib | T47D | 10.0 | uM | 24 | hr | 137.62 | 40.90 | p-Akt | 14.21 | |
| Torkinib | T47D | 10.0 | uM | 6 | hr | 152.43 | 69.07 | p-Akt | 14.87 | |