Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
Download: Excel (XLSX), Comma-separated (CSV)
| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| GSK1059615 | AU565 | 0 (control) | 24 | hr | 452.11 | 110.23 | p-Akt | 88.09 | | |
| Torkinib | MCF 10A | 0 (control) | 24 | hr | 335.16 | 114.92 | p-Akt | 54.49 | | |
| Gefitinib | HCC1954 | 0 (control) | 24 | hr | 342.49 | 120.54 | p-Akt | 84.26 | | |
| GSK1059615 | MCF 10A | 0 (control) | 24 | hr | 372.12 | 121.72 | p-Akt | 53.36 | | |
| MK2206 | T47D | 1.0 | nM | 24 | hr | 161.37 | 97.31 | p-Akt | 58.78 | |
| MK2206 | MCF 10A | 0 (control) | 24 | hr | 334.53 | 120.26 | p-Akt | 52.16 | | |
| Torkinib | HCC1954 | 0 (control) | 24 | hr | 309.60 | 109.35 | p-Akt | 76.75 | | |
| Triciribine | MCF 10A | 0 (control) | 24 | hr | 333.49 | 112.55 | p-Akt | 47.91 | | |
| MK2206 | AU565 | 0 (control) | 24 | hr | 427.04 | 124.23 | p-Akt | 78.88 | | |
| Dactolisib | MCF 10A | 0 (control) | 24 | hr | 351.94 | 125.18 | p-Akt | 50.36 | | |
| GSK1059615 | HCC1954 | 0 (control) | 24 | hr | 302.50 | 106.62 | p-Akt | 73.55 | | |
| Gefitinib | T47D | 0 (control) | 24 | hr | 177.88 | 116.19 | p-Akt | 85.23 | | |
| Torkinib | AU565 | 0 (control) | 24 | hr | 522.19 | 120.45 | p-Akt | 94.97 | | |
| Torkinib | T47D | 0 (control) | 24 | hr | 176.46 | 94.89 | p-Akt | 74.20 | | |
| MK2206 | HCC1954 | 0 (control) | 24 | hr | 288.09 | 111.00 | p-Akt | 78.02 | | |
| GSK1059615 | T47D | 0 (control) | 24 | hr | 168.24 | 91.00 | p-Akt | 67.96 | | |
| Triciribine | AU565 | 0 (control) | 24 | hr | 511.74 | 118.54 | p-Akt | 102.35 | | |
| MK2206 | T47D | 0 (control) | 24 | hr | 176.28 | 99.14 | p-Akt | 70.51 | | |
| Triciribine | HCC1954 | 0 (control) | 24 | hr | 282.25 | 98.69 | p-Akt | 60.55 | | |
| Triciribine | T47D | 0 (control) | 24 | hr | 186.87 | 92.32 | p-Akt | 71.34 | | |
| Gefitinib | AU565 | 0 (control) | 24 | hr | 659.08 | 130.41 | p-Akt | 134.35 | | |
| Dactolisib | T47D | 0 (control) | 24 | hr | 165.27 | 86.01 | p-Akt | 60.10 | | |
| Dactolisib | HCC1954 | 0 (control) | 24 | hr | 357.28 | 117.27 | p-Akt | 79.92 | | |
| Gefitinib | AU565 | 1.0 | nM | 24 | hr | 556.22 | 122.40 | p-Akt | 136.15 | |
| Torkinib | AU565 | 0.422 | nM | 24 | hr | 481.77 | 110.68 | p-Akt | 88.17 | |