Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Gefitinib | T47D | 3.16 | uM | 6 | hr | 166.54 | 105.20 | p-S6 | 470.44 | |
| Torkinib | T47D | 2.37 | uM | 6 | hr | 150.77 | 71.12 | p-S6 | 5.80 | |
| GSK1059615 | T47D | 3.16 | uM | 6 | hr | 155.38 | 59.43 | p-S6 | 5.70 | |
| MK2206 | T47D | 3.16 | uM | 6 | hr | 111.23 | 34.13 | p-S6 | 29.78 | |
| Triciribine | T47D | 3.16 | uM | 6 | hr | 104.79 | 44.18 | p-S6 | 46.47 | |
| Dactolisib | T47D | 3.16 | uM | 6 | hr | 99.22 | 33.03 | p-S6 | 4.39 | |
| Gefitinib | AU565 | 10.0 | uM | 6 | hr | 191.61 | 37.14 | p-S6 | 9.87 | |
| Torkinib | AU565 | 10.0 | uM | 6 | hr | 184.42 | 33.37 | p-S6 | 10.58 | |
| GSK1059615 | AU565 | 10.0 | uM | 6 | hr | 189.34 | 37.66 | p-S6 | 13.76 | |
| MK2206 | AU565 | 10.0 | uM | 6 | hr | 280.60 | 56.08 | p-S6 | 32.77 | |
| Triciribine | AU565 | 10.0 | uM | 6 | hr | 272.99 | 60.30 | p-S6 | 45.49 | |
| Dactolisib | AU565 | 10.0 | uM | 6 | hr | 189.90 | 41.38 | p-S6 | 10.76 | |
| Gefitinib | HCC1954 | 10.0 | uM | 6 | hr | 135.08 | 44.80 | p-S6 | 62.46 | |
| Torkinib | HCC1954 | 10.0 | uM | 6 | hr | 185.58 | 33.15 | p-S6 | 8.81 | |
| GSK1059615 | HCC1954 | 10.0 | uM | 6 | hr | 293.44 | 62.09 | p-S6 | 10.04 | |
| MK2206 | HCC1954 | 10.0 | uM | 6 | hr | 280.35 | 74.41 | p-S6 | 224.87 | |
| Triciribine | HCC1954 | 10.0 | uM | 6 | hr | 235.70 | 85.98 | p-S6 | 488.16 | |
| Dactolisib | HCC1954 | 10.0 | uM | 6 | hr | 271.28 | 75.36 | p-S6 | 19.47 | |
| Gefitinib | MCF 10A | 10.0 | uM | 6 | hr | 189.15 | 140.64 | p-S6 | 360.84 | |
| Torkinib | MCF 10A | 10.0 | uM | 6 | hr | 575.82 | 163.71 | p-S6 | 376.86 | |
| GSK1059615 | MCF 10A | 10.0 | uM | 6 | hr | 223.02 | 132.43 | p-S6 | 6.72 | |
| MK2206 | MCF 10A | 10.0 | uM | 6 | hr | 360.85 | 140.88 | p-S6 | 596.25 | |
| Triciribine | MCF 10A | 10.0 | uM | 6 | hr | 361.44 | 141.42 | p-S6 | 595.52 | |
| Dactolisib | MCF 10A | 10.0 | uM | 6 | hr | 325.09 | 126.50 | p-S6 | 407.13 | |
| Gefitinib | T47D | 10.0 | uM | 6 | hr | 156.59 | 103.96 | p-S6 | 496.01 | |