HMS LINCS Project

Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)

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Small molecules	Cells
10057:MK2206 10098:Gefitinib 10172:GSK1059615 10232:Dactolisib 10280:Triciribine 10345:Torkinib	50091:AU565 50213:HCC1954 50541:T47D 50583:MCF 10A

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Small Molecule	Cell Line	Drug Concentration	Conc Units	Timepoint	Timepoint Units	Measured pERK (Alexa 488)	Measured p-Rb (Alexa 568)	Alexa Fluor 647	Measured p-Akt/p-4EBP1/p-S6 (Alexa 647)	Image
Dactolisib	AU565	100.0	nM	24	hr	377.63	60.16	p-Akt	25.52
GSK1059615	MCF 10A	3.16	nM	24	hr	367.96	143.08	p-Akt	41.13
Gefitinib	HCC1954	100.0	nM	24	hr	271.49	112.65	p-Akt	74.36
MK2206	AU565	1.0	nM	24	hr	416.57	131.35	p-4EBP1	192.89
Torkinib	HCC1954	31.6	nM	24	hr	250.65	86.99	p-Akt	39.42
MK2206	MCF 10A	3.16	nM	24	hr	313.82	137.95	p-Akt	41.12
GSK1059615	HCC1954	100.0	nM	24	hr	285.12	84.64	p-Akt	37.56
Torkinib	HCC1954	0.1	nM	24	hr	292.92	106.38	p-Akt	66.25
MK2206	HCC1954	100.0	nM	24	hr	248.97	102.29	p-Akt	31.95
Triciribine	MCF 10A	3.16	nM	24	hr	272.12	127.39	p-Akt	34.72
Triciribine	HCC1954	100.0	nM	24	hr	238.17	94.17	p-Akt	36.41
MK2206	MCF 10A	0 (control)		24	hr	334.53	120.26	p-Akt	52.16
Dactolisib	HCC1954	100.0	nM	24	hr	240.30	68.59	p-Akt	21.56
Dactolisib	MCF 10A	3.16	nM	24	hr	306.83	142.69	p-Akt	34.75
Gefitinib	MCF 10A	100.0	nM	24	hr	258.63	122.31	p-Akt	28.67
GSK1059615	HCC1954	1.0	nM	24	hr	316.53	106.00	p-Akt	70.73
Torkinib	MCF 10A	31.6	nM	24	hr	400.54	150.17	p-Akt	24.66
Gefitinib	T47D	3.16	nM	24	hr	164.50	108.71	p-Akt	78.14
GSK1059615	MCF 10A	100.0	nM	24	hr	326.44	133.59	p-Akt	27.72
Torkinib	HCC1954	0 (control)		24	hr	309.60	109.35	p-Akt	76.75
MK2206	MCF 10A	100.0	nM	24	hr	301.03	149.65	p-Akt	23.12
Torkinib	T47D	0.422	nM	24	hr	165.87	94.49	p-Akt	59.39
Triciribine	MCF 10A	100.0	nM	24	hr	231.53	128.71	p-Akt	20.57
MK2206	HCC1954	1.0	nM	24	hr	287.05	111.38	p-Akt	67.97
Triciribine	HCC1954	1.0	nM	24	hr	303.58	117.35	p-4EBP1	135.97

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