Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Torkinib | AU565 | 0.1 | nM | 24 | hr | 500.67 | 124.40 | p-S6 | 484.77 | |
| Torkinib | AU565 | 31.6 | nM | 6 | hr | 280.52 | 52.21 | p-Akt | 15.00 | |
| Torkinib | HCC1954 | 0.1 | nM | 6 | hr | 184.63 | 45.52 | p-Akt | 20.62 | |
| Torkinib | AU565 | 0 (control) | 24 | hr | 520.08 | 134.68 | p-4EBP1 | 226.94 | | |
| Torkinib | HCC1954 | 0.1 | nM | 24 | hr | 300.36 | 112.32 | p-Akt | 67.70 | |
| Torkinib | AU565 | 0 (control) | 6 | hr | 294.05 | 67.35 | p-4EBP1 | 84.02 | | |
| Torkinib | HCC1954 | 133.0 | nM | 24 | hr | 222.17 | 88.12 | p-4EBP1 | 55.50 | |
| Torkinib | T47D | 0.422 | nM | 6 | hr | 177.20 | 86.68 | p-4EBP1 | 519.62 | |
| Torkinib | HCC1954 | 31.6 | nM | 6 | hr | 150.07 | 28.76 | p-Akt | 14.38 | |
| Torkinib | MCF 10A | 0.1 | nM | 24 | hr | 422.39 | 160.17 | p-S6 | 363.48 | |
| Torkinib | HCC1954 | 0 (control) | 6 | hr | 182.67 | 40.88 | p-Akt | 23.74 | | |
| Torkinib | T47D | 0.422 | nM | 24 | hr | 164.15 | 114.64 | p-4EBP1 | 409.39 | |
| Torkinib | MCF 10A | 0.1 | nM | 6 | hr | 483.02 | 168.09 | p-Akt | 48.88 | |
| Torkinib | T47D | 0.1 | nM | 6 | hr | 177.18 | 86.32 | p-Akt | 86.42 | |
| Torkinib | MCF 10A | 0.422 | nM | 6 | hr | 475.26 | 169.60 | p-Akt | 43.49 | |
| Torkinib | AU565 | 0.1 | nM | 6 | hr | 249.91 | 55.55 | p-Akt | 24.44 | |
| Torkinib | T47D | 0 (control) | 6 | hr | 175.86 | 85.25 | p-Akt | 102.65 | | |
| Torkinib | T47D | 10.0 | uM | 24 | hr | 125.57 | 36.99 | p-Akt | 13.71 | |
| Torkinib | T47D | 0 (control) | 24 | hr | 159.62 | 95.25 | p-Akt | 70.79 | | |
| Torkinib | AU565 | 0.1 | nM | 24 | hr | 513.30 | 118.22 | p-Akt | 83.59 | |
| Torkinib | T47D | 10.0 | uM | 6 | hr | 157.33 | 73.56 | p-Akt | 15.39 | |
| Torkinib | MCF 10A | 0 (control) | 24 | hr | 322.85 | 121.43 | p-Akt | 50.42 | | |
| Torkinib | T47D | 31.6 | nM | 6 | hr | 152.82 | 76.33 | p-4EBP1 | 310.16 | |
| Torkinib | MCF 10A | 0 (control) | 6 | hr | 536.28 | 163.68 | p-Akt | 59.35 | | |
| Torkinib | T47D | 7.5 | nM | 24 | hr | 144.08 | 65.96 | p-Akt | 33.04 | |