Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Triciribine | AU565 | 10.0 | nM | 6 | hr | 303.55 | 73.81 | p-4EBP1 | 96.67 | |
| Triciribine | AU565 | 10.0 | nM | 24 | hr | 483.38 | 131.11 | p-4EBP1 | 202.25 | |
| Triciribine | T47D | 0 (control) | 6 | hr | 93.67 | 36.69 | p-S6 | 48.97 | | |
| Triciribine | HCC1954 | 1.0 | nM | 24 | hr | 295.65 | 96.48 | p-Akt | 59.73 | |
| Triciribine | MCF 10A | 10.0 | uM | 24 | hr | 302.76 | 85.00 | p-Akt | 21.02 | |
| Triciribine | T47D | 3.16 | nM | 6 | hr | 96.97 | 52.42 | p-Akt | 20.09 | |
| Triciribine | HCC1954 | 10.0 | nM | 24 | hr | 300.41 | 117.49 | p-4EBP1 | 132.01 | |
| Triciribine | T47D | 3.16 | nM | 24 | hr | 157.47 | 91.95 | p-Akt | 63.67 | |
| Triciribine | T47D | 100.0 | nM | 6 | hr | 113.51 | 61.24 | p-Akt | 15.00 | |
| Triciribine | T47D | 100.0 | nM | 24 | hr | 172.96 | 80.38 | p-Akt | 42.98 | |
| Triciribine | MCF 10A | 1.0 | nM | 6 | hr | 401.41 | 156.95 | p-S6 | 411.77 | |
| Triciribine | AU565 | 0 (control) | 6 | hr | 231.71 | 61.01 | p-Akt | 21.54 | | |
| Triciribine | HCC1954 | 316.0 | nM | 24 | hr | 241.42 | 93.99 | p-Akt | 30.59 | |
| Triciribine | MCF 10A | 31.6 | nM | 6 | hr | 379.12 | 156.82 | p-4EBP1 | 360.76 | |
| Triciribine | HCC1954 | 3.16 | nM | 6 | hr | 275.93 | 96.79 | p-S6 | 400.96 | |
| Triciribine | MCF 10A | 1.0 | uM | 24 | hr | 304.69 | 113.47 | p-Akt | 20.17 | |
| Triciribine | MCF 10A | 1.0 | uM | 6 | hr | 373.41 | 152.18 | p-Akt | 19.21 | |
| Triciribine | T47D | 10.0 | nM | 6 | hr | 101.35 | 56.34 | p-4EBP1 | 175.96 | |
| Triciribine | MCF 10A | 3.16 | nM | 24 | hr | 267.46 | 146.10 | p-S6 | 248.42 | |
| Triciribine | T47D | 10.0 | uM | 6 | hr | 111.59 | 55.69 | p-Akt | 11.07 | |
| Triciribine | AU565 | 316.0 | nM | 6 | hr | 344.20 | 83.25 | p-Akt | 21.62 | |
| Triciribine | AU565 | 316.0 | nM | 24 | hr | 468.57 | 85.00 | p-Akt | 42.85 | |
| Triciribine | AU565 | 10.0 | nM | 24 | hr | 550.75 | 128.39 | p-S6 | 471.06 | |
| Triciribine | HCC1954 | 1.0 | uM | 24 | hr | 245.06 | 92.53 | p-Akt | 28.75 | |
| Triciribine | HCC1954 | 1.0 | uM | 6 | hr | 272.11 | 87.04 | p-Akt | 32.04 | |