Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Triciribine | AU565 | 1.0 | nM | 24 | hr | 492.56 | 131.78 | p-4EBP1 | 221.65 | |
| Triciribine | MCF 10A | 316.0 | nM | 24 | hr | 232.57 | 125.08 | p-Akt | 18.69 | |
| Triciribine | MCF 10A | 316.0 | nM | 6 | hr | 375.95 | 152.24 | p-4EBP1 | 348.65 | |
| Triciribine | MCF 10A | 316.0 | nM | 24 | hr | 246.69 | 149.87 | p-4EBP1 | 169.66 | |
| Triciribine | T47D | 316.0 | nM | 24 | hr | 167.32 | 71.34 | p-Akt | 37.26 | |
| Triciribine | HCC1954 | 31.6 | nM | 6 | hr | 250.28 | 91.52 | p-4EBP1 | 117.60 | |
| Triciribine | MCF 10A | 3.16 | nM | 6 | hr | 404.45 | 155.90 | p-Akt | 44.15 | |
| Triciribine | HCC1954 | 1.0 | nM | 6 | hr | 192.23 | 55.17 | p-Akt | 31.66 | |
| Triciribine | MCF 10A | 3.16 | nM | 24 | hr | 272.12 | 127.39 | p-Akt | 34.72 | |
| Triciribine | HCC1954 | 100.0 | nM | 6 | hr | 200.10 | 73.80 | p-Akt | 29.38 | |
| Triciribine | HCC1954 | 100.0 | nM | 24 | hr | 238.17 | 94.17 | p-Akt | 36.41 | |
| Triciribine | HCC1954 | 1.0 | nM | 6 | hr | 235.54 | 85.78 | p-4EBP1 | 104.82 | |
| Triciribine | MCF 10A | 0 (control) | 6 | hr | 477.54 | 163.37 | p-Akt | 60.15 | | |
| Triciribine | MCF 10A | 1.0 | nM | 24 | hr | 266.33 | 138.95 | p-4EBP1 | 314.28 | |
| Triciribine | T47D | 1.0 | uM | 24 | hr | 159.21 | 77.45 | p-4EBP1 | 335.03 | |
| Triciribine | AU565 | 3.16 | uM | 6 | hr | 287.03 | 70.34 | p-4EBP1 | 75.61 | |
| Triciribine | MCF 10A | 3.16 | uM | 24 | hr | 279.48 | 109.63 | p-Akt | 20.65 | |
| Triciribine | MCF 10A | 1.0 | nM | 6 | hr | 427.06 | 161.76 | p-4EBP1 | 385.00 | |
| Triciribine | MCF 10A | 3.16 | uM | 6 | hr | 360.15 | 139.85 | p-4EBP1 | 338.46 | |
| Triciribine | MCF 10A | 3.16 | uM | 6 | hr | 370.92 | 146.93 | p-Akt | 17.67 | |
| Triciribine | MCF 10A | 0 (control) | 24 | hr | 333.49 | 112.55 | p-Akt | 47.91 | | |
| Triciribine | MCF 10A | 100.0 | nM | 6 | hr | 360.87 | 152.35 | p-Akt | 25.66 | |
| Triciribine | MCF 10A | 100.0 | nM | 24 | hr | 231.53 | 128.71 | p-Akt | 20.57 | |
| Triciribine | HCC1954 | 31.6 | nM | 6 | hr | 244.04 | 84.91 | p-Akt | 40.97 | |
| Triciribine | AU565 | 31.6 | nM | 24 | hr | 529.95 | 113.46 | p-Akt | 82.44 | |