Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Triciribine | MCF 10A | 1.0 | nM | 6 | hr | 468.07 | 156.41 | p-4EBP1 | 394.50 | |
| Torkinib | MCF 10A | 133.0 | nM | 24 | hr | 438.54 | 156.39 | p-4EBP1 | 79.88 | |
| Gefitinib | MCF 10A | 10.0 | nM | 24 | hr | 269.57 | 156.39 | p-4EBP1 | 207.59 | |
| MK2206 | MCF 10A | 100.0 | nM | 24 | hr | 273.76 | 156.36 | p-S6 | 238.51 | |
| Dactolisib | MCF 10A | 10.0 | nM | 6 | hr | 353.43 | 156.34 | p-S6 | 500.28 | |
| Triciribine | MCF 10A | 3.16 | nM | 6 | hr | 389.81 | 156.34 | p-S6 | 538.30 | |
| MK2206 | MCF 10A | 100.0 | nM | 24 | hr | 285.48 | 156.23 | p-S6 | 281.30 | |
| MK2206 | MCF 10A | 1.0 | nM | 6 | hr | 426.62 | 156.09 | p-S6 | 543.93 | |
| Triciribine | MCF 10A | 0 (control) | 6 | hr | 451.65 | 156.02 | p-S6 | 578.30 | | |
| Triciribine | MCF 10A | 100.0 | nM | 24 | hr | 233.97 | 155.96 | p-4EBP1 | 184.14 | |
| Triciribine | MCF 10A | 3.16 | nM | 6 | hr | 404.45 | 155.90 | p-Akt | 44.15 | |
| MK2206 | MCF 10A | 3.16 | uM | 6 | hr | 374.51 | 155.85 | p-S6 | 642.84 | |
| MK2206 | MCF 10A | 0 (control) | 6 | hr | 449.92 | 155.83 | p-S6 | 579.06 | | |
| Triciribine | MCF 10A | 10.0 | nM | 6 | hr | 393.14 | 155.67 | p-S6 | 439.99 | |
| MK2206 | MCF 10A | 3.16 | nM | 6 | hr | 387.67 | 155.66 | p-S6 | 537.91 | |
| Torkinib | MCF 10A | 133.0 | nM | 24 | hr | 530.52 | 155.64 | p-S6 | 629.03 | |
| Triciribine | MCF 10A | 10.0 | nM | 6 | hr | 383.05 | 155.63 | p-4EBP1 | 371.60 | |
| Torkinib | MCF 10A | 0 (control) | 6 | hr | 502.64 | 155.63 | p-4EBP1 | 400.80 | | |
| MK2206 | MCF 10A | 1.0 | nM | 6 | hr | 464.75 | 155.56 | p-4EBP1 | 392.89 | |
| Torkinib | MCF 10A | 0 (control) | 6 | hr | 487.61 | 155.47 | p-S6 | 474.69 | | |
| MK2206 | MCF 10A | 31.6 | nM | 6 | hr | 375.80 | 155.36 | p-4EBP1 | 359.32 | |
| Triciribine | MCF 10A | 10.0 | nM | 6 | hr | 380.71 | 155.18 | p-Akt | 33.02 | |
| Torkinib | MCF 10A | 0.1 | nM | 6 | hr | 458.56 | 155.16 | p-Akt | 49.17 | |
| Dactolisib | MCF 10A | 3.16 | nM | 24 | hr | 263.37 | 155.04 | p-4EBP1 | 239.83 | |
| Torkinib | MCF 10A | 2.37 | uM | 6 | hr | 620.84 | 155.04 | p-Akt | 19.11 | |