Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Triciribine | MCF 10A | 10.0 | uM | 6 | hr | 361.44 | 141.42 | p-S6 | 595.52 | |
| Torkinib | MCF 10A | 7.5 | nM | 24 | hr | 488.46 | 184.47 | p-S6 | 594.52 | |
| Triciribine | HCC1954 | 1.0 | uM | 6 | hr | 283.58 | 95.51 | p-S6 | 590.30 | |
| Triciribine | HCC1954 | 3.16 | uM | 6 | hr | 296.11 | 94.58 | p-S6 | 589.19 | |
| Dactolisib | MCF 10A | 3.16 | nM | 6 | hr | 371.03 | 152.85 | p-S6 | 587.69 | |
| GSK1059615 | AU565 | 1.0 | nM | 24 | hr | 458.33 | 123.46 | p-S6 | 585.14 | |
| Gefitinib | MCF 10A | 10.0 | nM | 24 | hr | 413.04 | 188.00 | p-S6 | 584.31 | |
| GSK1059615 | MCF 10A | 100.0 | nM | 24 | hr | 401.51 | 187.40 | p-S6 | 583.76 | |
| MK2206 | MCF 10A | 0 (control) | 6 | hr | 449.92 | 155.83 | p-S6 | 579.06 | | |
| Triciribine | MCF 10A | 0 (control) | 6 | hr | 451.65 | 156.02 | p-S6 | 578.30 | | |
| Torkinib | MCF 10A | 7.5 | nM | 6 | hr | 466.14 | 166.31 | p-S6 | 576.27 | |
| Dactolisib | MCF 10A | 0 (control) | 6 | hr | 464.95 | 166.23 | p-S6 | 565.63 | | |
| Torkinib | MCF 10A | 31.6 | nM | 6 | hr | 512.25 | 160.72 | p-S6 | 563.19 | |
| Torkinib | MCF 10A | 1.78 | nM | 6 | hr | 478.51 | 162.83 | p-S6 | 559.27 | |
| MK2206 | MCF 10A | 10.0 | nM | 6 | hr | 378.43 | 163.08 | p-S6 | 558.71 | |
| Gefitinib | AU565 | 3.16 | nM | 24 | hr | 571.55 | 130.70 | p-S6 | 558.33 | |
| Triciribine | MCF 10A | 10.0 | nM | 6 | hr | 379.91 | 163.67 | p-S6 | 558.18 | |
| Torkinib | MCF 10A | 2.37 | uM | 6 | hr | 625.54 | 171.57 | p-S6 | 556.27 | |
| Gefitinib | MCF 10A | 10.0 | nM | 6 | hr | 400.06 | 177.82 | p-S6 | 554.57 | |
| Torkinib | MCF 10A | 0.422 | nM | 6 | hr | 430.95 | 160.56 | p-S6 | 549.49 | |
| GSK1059615 | AU565 | 3.16 | nM | 24 | hr | 451.76 | 117.41 | p-S6 | 545.16 | |
| Triciribine | MCF 10A | 1.0 | nM | 6 | hr | 427.45 | 156.76 | p-S6 | 544.61 | |
| Triciribine | MCF 10A | 31.6 | nM | 6 | hr | 369.27 | 161.18 | p-S6 | 544.27 | |
| MK2206 | MCF 10A | 1.0 | nM | 6 | hr | 426.62 | 156.09 | p-S6 | 543.93 | |
| Triciribine | MCF 10A | 316.0 | nM | 6 | hr | 347.05 | 158.30 | p-S6 | 541.94 | |