Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| MK2206 | AU565 | 31.6 | nM | 24 | hr | 405.92 | 121.43 | p-S6 | 442.43 | |
| Gefitinib | T47D | 10.0 | uM | 6 | hr | 154.80 | 87.88 | p-4EBP1 | 442.33 | |
| Gefitinib | AU565 | 316.0 | nM | 24 | hr | 422.43 | 94.36 | p-S6 | 441.87 | |
| Gefitinib | T47D | 3.16 | nM | 6 | hr | 191.33 | 107.09 | p-S6 | 441.08 | |
| Triciribine | T47D | 1.0 | uM | 24 | hr | 160.74 | 72.11 | p-S6 | 440.48 | |
| Triciribine | MCF 10A | 10.0 | nM | 6 | hr | 393.14 | 155.67 | p-S6 | 439.99 | |
| Dactolisib | MCF 10A | 31.6 | nM | 6 | hr | 370.10 | 148.60 | p-S6 | 439.13 | |
| Gefitinib | T47D | 3.16 | nM | 6 | hr | 176.59 | 102.38 | p-S6 | 438.72 | |
| Torkinib | HCC1954 | 31.6 | nM | 24 | hr | 266.32 | 99.88 | p-S6 | 438.02 | |
| MK2206 | MCF 10A | 10.0 | nM | 6 | hr | 390.73 | 154.71 | p-S6 | 437.85 | |
| Gefitinib | MCF 10A | 3.16 | uM | 6 | hr | 196.68 | 148.61 | p-S6 | 437.61 | |
| Triciribine | T47D | 10.0 | uM | 24 | hr | 195.69 | 74.52 | p-S6 | 435.43 | |
| Torkinib | T47D | 7.5 | nM | 6 | hr | 162.62 | 84.08 | p-4EBP1 | 434.94 | |
| MK2206 | AU565 | 31.6 | nM | 24 | hr | 359.57 | 111.63 | p-S6 | 433.19 | |
| MK2206 | MCF 10A | 3.16 | uM | 24 | hr | 366.22 | 144.25 | p-S6 | 433.13 | |
| MK2206 | HCC1954 | 1.0 | nM | 6 | hr | 324.58 | 90.78 | p-S6 | 432.26 | |
| Triciribine | HCC1954 | 1.0 | nM | 6 | hr | 273.39 | 95.53 | p-S6 | 432.10 | |
| GSK1059615 | T47D | 0 (control) | 24 | hr | 164.30 | 107.15 | p-4EBP1 | 431.40 | | |
| Triciribine | T47D | 316.0 | nM | 24 | hr | 161.05 | 81.18 | p-S6 | 431.20 | |
| Triciribine | T47D | 100.0 | nM | 24 | hr | 172.21 | 96.81 | p-S6 | 431.18 | |
| Triciribine | T47D | 3.16 | uM | 24 | hr | 163.59 | 74.05 | p-S6 | 431.08 | |
| MK2206 | HCC1954 | 3.16 | nM | 6 | hr | 319.23 | 90.52 | p-S6 | 430.33 | |
| GSK1059615 | MCF 10A | 1.0 | nM | 24 | hr | 485.63 | 165.59 | p-S6 | 430.02 | |
| MK2206 | HCC1954 | 10.0 | nM | 6 | hr | 303.44 | 88.14 | p-S6 | 429.68 | |
| Torkinib | MCF 10A | 0.1 | nM | 24 | hr | 440.38 | 152.72 | p-S6 | 429.06 | |