Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Dactolisib | HCC1954 | 316.0 | nM | 6 | hr | 193.59 | 49.84 | p-Akt | 12.54 | |
| Dactolisib | HCC1954 | 10.0 | uM | 6 | hr | 280.52 | 78.67 | p-4EBP1 | 11.05 | |
| Dactolisib | HCC1954 | 10.0 | nM | 6 | hr | 192.04 | 59.35 | p-Akt | 27.50 | |
| Dactolisib | HCC1954 | 0 (control) | 6 | hr | 255.38 | 84.53 | p-4EBP1 | 99.75 | | |
| Dactolisib | HCC1954 | 10.0 | uM | 6 | hr | 271.28 | 75.36 | p-S6 | 19.47 | |
| Dactolisib | HCC1954 | 3.16 | nM | 6 | hr | 182.51 | 40.62 | p-Akt | 20.25 | |
| Dactolisib | HCC1954 | 3.16 | nM | 6 | hr | 197.54 | 49.32 | p-S6 | 74.13 | |
| Dactolisib | HCC1954 | 0 (control) | 6 | hr | 264.91 | 93.02 | p-Akt | 54.82 | | |
| Dactolisib | HCC1954 | 1.0 | uM | 6 | hr | 235.17 | 64.66 | p-Akt | 16.95 | |
| Dactolisib | HCC1954 | 31.6 | nM | 6 | hr | 190.11 | 67.14 | p-4EBP1 | 26.14 | |
| Dactolisib | HCC1954 | 316.0 | nM | 6 | hr | 231.85 | 69.00 | p-S6 | 9.96 | |
| Dactolisib | HCC1954 | 0 (control) | 6 | hr | 184.34 | 66.18 | p-S6 | 158.93 | | |
| Dactolisib | HCC1954 | 1.0 | uM | 6 | hr | 209.83 | 60.36 | p-Akt | 16.60 | |
| Dactolisib | HCC1954 | 1.0 | nM | 6 | hr | 221.39 | 85.08 | p-S6 | 226.60 | |
| Dactolisib | HCC1954 | 3.16 | uM | 6 | hr | 231.49 | 70.49 | p-S6 | 12.72 | |
| Dactolisib | HCC1954 | 31.6 | nM | 6 | hr | 236.72 | 75.54 | p-Akt | 26.13 | |
| Dactolisib | HCC1954 | 10.0 | nM | 6 | hr | 225.45 | 79.13 | p-4EBP1 | 63.25 | |
| Dactolisib | HCC1954 | 31.6 | nM | 6 | hr | 155.80 | 36.19 | p-S6 | 9.19 | |
| Dactolisib | HCC1954 | 3.16 | uM | 6 | hr | 233.33 | 68.76 | p-4EBP1 | 8.74 | |
| Dactolisib | HCC1954 | 316.0 | nM | 6 | hr | 220.49 | 67.32 | p-4EBP1 | 10.28 | |
| Dactolisib | HCC1954 | 3.16 | nM | 6 | hr | 156.03 | 43.22 | p-4EBP1 | 57.72 | |
| Dactolisib | HCC1954 | 1.0 | uM | 6 | hr | 254.85 | 75.26 | p-4EBP1 | 10.90 | |
| Dactolisib | HCC1954 | 1.0 | nM | 6 | hr | 188.42 | 59.42 | p-Akt | 32.78 | |
| Dactolisib | HCC1954 | 31.6 | nM | 6 | hr | 211.19 | 76.64 | p-S6 | 11.83 | |
| Dactolisib | HCC1954 | 100.0 | nM | 6 | hr | 173.90 | 40.33 | p-Akt | 15.09 | |