Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Torkinib | AU565 | 7.5 | nM | 24 | hr | 463.58 | 90.29 | p-Akt | 56.28 | |
| Torkinib | MCF 10A | 7.5 | nM | 6 | hr | 466.14 | 166.31 | p-S6 | 576.27 | |
| Torkinib | MCF 10A | 7.5 | nM | 24 | hr | 455.61 | 175.00 | p-S6 | 479.38 | |
| Torkinib | HCC1954 | 7.5 | nM | 24 | hr | 261.97 | 105.02 | p-S6 | 381.35 | |
| Torkinib | MCF 10A | 7.5 | nM | 6 | hr | 516.67 | 184.66 | p-S6 | 775.89 | |
| Torkinib | HCC1954 | 7.5 | nM | 6 | hr | 166.69 | 28.86 | p-Akt | 16.56 | |
| Torkinib | T47D | 7.5 | nM | 6 | hr | 157.46 | 86.43 | p-Akt | 48.47 | |
| Torkinib | AU565 | 7.5 | nM | 24 | hr | 465.15 | 97.95 | p-S6 | 212.59 | |
| Torkinib | AU565 | 7.5 | nM | 6 | hr | 240.99 | 44.76 | p-Akt | 15.24 | |
| Torkinib | HCC1954 | 7.5 | nM | 24 | hr | 251.11 | 94.12 | p-Akt | 46.29 | |
| Torkinib | HCC1954 | 7.5 | nM | 6 | hr | 176.66 | 32.26 | p-4EBP1 | 41.13 | |
| Torkinib | AU565 | 7.5 | nM | 24 | hr | 440.89 | 99.20 | p-4EBP1 | 147.59 | |
| Torkinib | AU565 | 7.5 | nM | 6 | hr | 237.10 | 47.79 | p-4EBP1 | 50.80 | |
| Torkinib | MCF 10A | 7.5 | nM | 6 | hr | 448.64 | 163.43 | p-4EBP1 | 292.01 | |
| Torkinib | MCF 10A | 7.5 | nM | 24 | hr | 362.68 | 177.31 | p-4EBP1 | 160.77 | |
| Torkinib | MCF 10A | 7.5 | nM | 6 | hr | 427.52 | 157.79 | p-Akt | 37.03 | |
| Torkinib | MCF 10A | 7.5 | nM | 24 | hr | 366.02 | 147.83 | p-Akt | 35.28 | |
| Torkinib | T47D | 7.5 | nM | 24 | hr | 138.86 | 70.27 | p-Akt | 34.18 | |
| Torkinib | AU565 | 7.5 | nM | 6 | hr | 277.07 | 52.38 | p-4EBP1 | 54.13 | |
| Torkinib | HCC1954 | 7.5 | nM | 6 | hr | 264.08 | 62.91 | p-4EBP1 | 67.81 | |
| Torkinib | HCC1954 | 7.5 | nM | 24 | hr | 266.85 | 111.10 | p-4EBP1 | 127.79 | |
| Torkinib | T47D | 7.5 | nM | 24 | hr | 144.08 | 65.96 | p-Akt | 33.04 | |
| Torkinib | HCC1954 | 7.5 | nM | 6 | hr | 176.81 | 34.82 | p-S6 | 63.14 | |
| Torkinib | MCF 10A | 562.0 | nM | 6 | hr | 543.48 | 156.73 | p-S6 | 529.47 | |
| Torkinib | HCC1954 | 562.0 | nM | 24 | hr | 245.07 | 75.47 | p-S6 | 11.19 | |