HMS LINCS Project

Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)

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Small molecules	Cells
10057:MK2206 10098:Gefitinib 10172:GSK1059615 10232:Dactolisib 10280:Triciribine 10345:Torkinib	50091:AU565 50213:HCC1954 50541:T47D 50583:MCF 10A

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Small Molecule	Cell Line	Drug Concentration	Conc Units	Timepoint	Timepoint Units	Measured pERK (Alexa 488)	Measured p-Rb (Alexa 568)	Alexa Fluor 647	Measured p-Akt/p-4EBP1/p-S6 (Alexa 647)	Image
Gefitinib	T47D	100.0	nM	6	hr	165.65	99.07	p-Akt	102.82
Gefitinib	T47D	100.0	nM	24	hr	153.51	95.94	p-Akt	73.78
Torkinib	T47D	31.6	nM	6	hr	157.45	81.63	p-Akt	32.89
Torkinib	T47D	31.6	nM	24	hr	120.65	41.23	p-Akt	22.89
GSK1059615	T47D	100.0	nM	6	hr	158.85	79.78	p-Akt	56.09
GSK1059615	T47D	100.0	nM	24	hr	151.19	70.37	p-Akt	36.54
MK2206	T47D	100.0	nM	6	hr	95.92	42.78	p-Akt	7.64
MK2206	T47D	100.0	nM	24	hr	135.00	67.06	p-Akt	17.61
Triciribine	T47D	100.0	nM	6	hr	113.51	61.24	p-Akt	15.00
Triciribine	T47D	100.0	nM	24	hr	172.96	80.38	p-Akt	42.98
Dactolisib	T47D	100.0	nM	6	hr	101.93	53.36	p-Akt	8.50
Dactolisib	T47D	100.0	nM	24	hr	121.98	38.12	p-Akt	19.84
Dactolisib	T47D	3.16	nM	24	hr	138.41	87.20	p-Akt	40.75
MK2206	T47D	3.16	uM	6	hr	117.01	52.23	p-Akt	7.58
Gefitinib	T47D	316.0	nM	24	hr	159.76	114.64	p-Akt	81.98
Triciribine	T47D	3.16	uM	24	hr	169.39	62.41	p-Akt	33.47
Triciribine	T47D	3.16	uM	6	hr	117.72	59.79	p-Akt	12.45
Dactolisib	T47D	3.16	uM	6	hr	86.04	36.41	p-Akt	6.31
Dactolisib	T47D	3.16	uM	24	hr	119.38	40.84	p-Akt	13.33
Gefitinib	T47D	0 (control)		6	hr	176.65	97.90	p-Akt	103.18
Gefitinib	T47D	100.0	nM	24	hr	143.88	111.89	p-4EBP1	390.92
Torkinib	T47D	31.6	nM	24	hr	124.43	49.09	p-4EBP1	182.93
GSK1059615	T47D	100.0	nM	6	hr	161.08	79.36	p-4EBP1	506.97
Dactolisib	T47D	31.6	nM	24	hr	124.69	58.78	p-S6	12.06
Dactolisib	T47D	31.6	nM	6	hr	90.16	29.57	p-S6	4.68

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